BBS4

Gene Symbol BBS4
Entrez Gene 585
Alt Symbol -
Species Human
Gene Type protein-coding
Description Bardet-Biedl syndrome 4
Other Description Bardet-Biedl syndrome 4 protein
Swissprots Q96RK4 Q96H45 Q8NHU9 Q53DZ5 B4E178
Accessions EAW77912 EAW77913 Q96RK4 AF359281 AAK58868 AK075321 BAC11547 AK298922 BAG61027 AK302224 BAH13654 AK303706 BAG64690 AK310106 AK314507 BAG37107 AY457143 AAS13441 BC008923 AAH08923 BC027624 AAH27624 BI562463 BM664845 BX647855 DC320069 DC372967 DQ891519 ABM82445 DQ894709 ABM85635 XM_006720625 XP_006720688 XM_011521848 XP_011520150 XM_011521849 XP_011520151 XM_011521850 XP_011520152 XM_011521851 XP_011520153 NM_001252678 NP_001239607 NM_033028 NP_149017 NR_045565 NR_045566
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium, flagellum {ECO:0000250}. Note=Localizes to the pericentriolar region throughout the cell cycle. Centrosomal localization requires dynein.
Tissue Specificity Ubiquitously expressed. The highest level of expression is found in the kidney.

BBS4 (H-304) - sc-67201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BBS4 (H-304): sc-67201. Western blot analysis of BBS4 expression in mouse heart (A), rat heart (B) and rat kidney (C) tissue extracts.

BBS4 (E-20) - sc-49386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

BBS4 (N-19) - sc-49387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

BBS4 (F-24) - sc-130699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
BBS4 (F-24): sc-130699. Western blot analysis of BBS4 expression in HeLa whole cell lysate.

Anti-BBS4 antibody - ab71454 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BBS4 antibody (ab71454) at 1/60 dilution + HeLa cell line lysate at 12.5 µgObserved band size : 50 kDa (why is the actual band size different from the predicted?)

Anti-BBS4 antibody - ab67189 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-BBS4 antibody (ab67189) at 1/500 dilutionLane 1 : BBS4 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg/ml per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-BBS4 antibody [1292CT845.130.218] - ab188364 from Abcam

Prices $370.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1292CT845.130.218
All lanes : Anti-BBS4 antibody [1292CT845.130.218] (ab188364) at 1/1000 dilutionLane 1 : HeLa lysateLane 2 : U251 lysateLane 3 : Mouse heart lysateLane 4 : Mouse kidney lysateLane 5 : Rat heart lysateLane 6 : Rat kidney lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-mouse IgG H&L(HRP) at 1/3000 dilution

Anti-BBS4 antibody - N-terminal - ab86159 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-BBS4 Antibody - LS-C306508 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-BBS4 Antibody - LS-C309586 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BBS4 Antibody - LS-C309588 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BBS4 Antibody (aa215-264) - LS-C116738 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BBS4 antibody LS-C116738 Western blot of HepG2 cell lysate.

Anti-BBS4 Antibody (aa71-120) - LS-C116737 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BBS4 antibody LS-C116737 Western blot of HepG2 cell lysate.

Anti-BBS4 Antibody (aa125-139) - LS-C139722 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
BBS4 antibody (1 ug/ml) staining of HeLa lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-BBS4 Antibody (aa33-46) - LS-C139721 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
BBS4 antibody (1 ug/ml) staining of Human Testis lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-BBS4 Antibody (aa266-519, clone 2D5) - LS-C339228 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BBS4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BBS4.

Anti-BBS4 Antibody (aa337-369) - LS-C100183 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of BBS4 Antibody antibody pre-incubated without(lane 1) and with(lane 2) blocking peptide in A549 cell line lysate. BBS4 Antibody (arrow) was detected using the purified antibody.

Anti-BBS4 Antibody (aa1-240, clone 1292CT845.130.218) - LS-C344122 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1292CT845.130.218
Western blot of lysates from HeLa, U251 cell line, mouse heart and kidney, rat heart and kidney tissue (from left to right) with PHB Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

BBS4 Antibody - NBP1-86248 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BBS4 Antibody [NBP1-86248] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4

BBS4 Antibody (1292CT845.130.218) - NBP2-32308 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1292CT845.130.218
Western Blot: BBS4 Antibody (1292CT845.130.218) [NBP2-32308] - Western blot analysis of lysates from Hela, U251 cell line, mouse heart and kidney, rat heart and kidney tissue (from left to right) using PHB Antibody. NBP2-32308 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

BBS4 Antibody - NBP1-68873 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: BBS4 Antibody [NBP1-68873] - NBP1-68873 (1ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

BBS4 Antibody - NBP1-68872 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: BBS4 Antibody [NBP1-68872] - (1ug/ml) Analysis of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

BBS4 Antibody - H00000585-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: BBS4 Antibody [H00000585-B01P] - Analysis of BBS4 expression in transfected 293T cell line by BBS4 polyclonal antibody. Lane 1: BBS4 transfected lysate(57.09 KDa). Lane 2: Non-transfected lysate.

BBS4 Antibody - H00000585-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: BBS4 Antibody [H00000585-B01] - analysis of BBS4 expression in transfected 293T cell line by BBS4 MaxPab polyclonal antibody (B01). Lane 1: BBS4 transfected lysate (58.30 KDa). Lane 2: Non-transfected lysate.

BBS4 Antibody - H00000585-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: BBS4 Antibody [H00000585-D01P] - Analysis of BBS4 expression in mouse liver.
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