BBS4

Gene Symbol	BBS4
Entrez Gene	585
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	Bardet-Biedl syndrome 4
Other Description	Bardet-Biedl syndrome 4 protein
Swissprots	Q96RK4 Q96H45 Q8NHU9 Q53DZ5 B4E178
Accessions	EAW77912 EAW77913 Q96RK4 AF359281 AAK58868 AK075321 BAC11547 AK298922 BAG61027 AK302224 BAH13654 AK303706 BAG64690 AK310106 AK314507 BAG37107 AY457143 AAS13441 BC008923 AAH08923 BC027624 AAH27624 BI562463 BM664845 BX647855 DC320069 DC372967 DQ891519 ABM82445 DQ894709 ABM85635 XM_006720625 XP_006720688 XM_011521848 XP_011520150 XM_011521849 XP_011520151 XM_011521850 XP_011520152 XM_011521851 XP_011520153 NM_001252678 NP_001239607 NM_033028 NP_149017 NR_045565 NR_045566
Function	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium, flagellum {ECO:0000250}. Note=Localizes to the pericentriolar region throughout the cell cycle. Centrosomal localization requires dynein.
Tissue Specificity	Ubiquitously expressed. The highest level of expression is found in the kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BBS4-Over-expression-Lysate - LY11679a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

BBS4 Lysate(Denatured) - H00000585-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

BBS4 293 Cell Lysate - 405082 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

BBS4 Overexpression Lysate (Denatured) - H00000585-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

BBS4 Overexpression Lysate (Native) - NBL1-07929 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BBS4 Over-expression Lysate Product - GWB-90BFA8 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human BBS4 Knockdown Stable Cell Line - CSC-DC001344 from Creative biogene Category Cell Line Species Human

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