| Gene Symbol | ENPP3 |
|---|---|
| Entrez Gene | 5169 |
| Alt Symbol | B10, CD203c, NPP3, PD-IBETA, PDNP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| Other Description | dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)|dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)|ectonucleotide pyrophosphatase/phosphodiesterase family member 3|gp130RB13-6|phosphodiesterase I/nucleotide pyrophosphatase 3|phosphodiesterase-I beta |
| Swissprots | O14638 Q5JTL3 |
| Accessions | AAD05192 AAD46160 CAB99214 CCA64000 CDH92907 EAW48044 EAW48045 EAW48046 O14638 AK024899 AK226107 AK292903 BAF85592 AK296080 BAG58836 AK309080 AK310691 AK315893 BAF98784 BC141434 AAI41435 BC146579 AAI46580 DB230886 DB239180 DQ234347 ABB29976 EF560735 ABQ59045 XM_011535897 XP_011534199 XR_245539 NM_005021 NP_005012 |
| Function | Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:15072822}. Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells. |
| Tissue Specificity | Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells and their progenitors. {ECO:0000269|PubMed:15072822, ECO:0000269|PubMed:9344668}. |
| Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Riboflavin metabolism, Pantothenate and CoA biosynthesis, Starch and sucrose metabolism |