NPC2

Gene Symbol	NPC2
Entrez Gene	403920
Alt Symbol	CE1
Species	Dog
Gene Type	protein-coding
Description	Niemann-Pick disease, type C2
Other Description	epididymal secretory protein E1|niemann Pick type C2 protein homolog
Swissprots	Q28895
Accessions	Q28895 DN346847 DN348892 DN349868 DN392295 S77411 AAB34263 NM_001003242 NP_001003242
Function	Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000305}. Endoplasmic reticulum {ECO:0000250}. Lysosome {ECO:0000250}.
Tissue Specificity	Epididymis. High levels are found in the caput and corpus regions. Weaker levels in the distal cauda and in the efferent ducts. {ECO:0000269|PubMed:7744512}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides

Dog NPC2 protein - orb244836 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Dog

Yeast NPC protein - orb246161 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Yeast

Recombinant Canis familiaris (Dog) Epididymal secretory protein E1 - CSB-YP634688DO CSB-BP634688DO CSB-MP634688DO from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Dog

Recombinant Dog Epididymal secretory protein E1(NPC2) - CSB-EP634688DO from Cusabio Category Protein Source Yeast Species Dog

Recombinant Canis familiaris (Dog) Epididymal secretory protein E1 - CSB-EP634688DO(S) from Cusabio Category Protein Source E.coli Species Dog

Recombinant Dog Epididymal secretory protein E1(NPC2) - CSB-YP634688DO from Cusabio Category Protein Source Yeast Species Dog

Recombinant Dog Epididymal secretory protein E1(NPC2) - CSB-MP634688DO from Cusabio Category Protein Source Yeast Species Dog

Recombinant Dog Epididymal secretory protein E1(NPC2) - CSB-BP634688DO from Cusabio Category Protein Source Yeast Species Dog

NPC2 Recombinant Protein (OPCA02273) - OPCA02273 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Dog

NPC Recombinant Protein (OPCA03014) - OPCA03014 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Dog

NPC2 Recombinant Protein (OPCA03472) - OPCA03472 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Dog

Dog NPC2 protein - orb358730 from Biorbyt Category Protein Prices $366.00, $595.00, $986.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Dog

Dog NPC2 protein - orb54083 from Biorbyt Category Protein Prices $213.00, $408.00, $612.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Dog

Dog NPC2 protein - orb54128 from Biorbyt Category Protein Prices $213.00, $408.00, $612.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Dog

Recombinant Canis familiaris (Dog) Epididymal secretory protein E1 - AP71307 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Dog

Recombinant Epididymal secretory protein E1 - AP73062 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

Epididymal secretory protein E1, Recombinant Protein - MBS1319431 from MyBioSource Category Protein Prices $185.00, $420.00, $680.00, $1,070.00 Sizes 50 µg (Yeast), 200 µg (Yeast), 500 µg (Yeast), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Epididymal secretory protein E1, Recombinant Protein - MBS9421175 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli

Epididymal secretory protein E1, Recombinant Protein - MBS9422758 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

Epididymal secretory protein E1, Recombinant Protein - MBS969721 from MyBioSource Category Protein Prices $110.00, $190.00, $460.00, $750.00, $1,180.00 Sizes 10 µg (E-Coli), 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Dog

Dog NPC2 protein - orb418814 from Biorbyt Category Protein Species Dog

Recombinant Dog NPC2 Protein (22-149 aa), His-tagged - NPC2-1018D from Creative Biomart Category Protein Source E. coli Species Dog

Recombinant Dog NPC2 Protein (22-149 aa), His-tagged - NPC2-1665D from Creative Biomart Category Protein Source Yeast Species Dog

Search more