| Gene Symbol |
PUM2
|
| Entrez Gene |
23369
|
| Alt Symbol |
PUMH2, PUML2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pumilio RNA-binding family member 2
|
| Other Description |
pumilio homolog 2|pumilio-2
|
| Swissprots |
B3KSL0 Q9HAN2 Q8WY43 Q53TV7 B4E2B6 O00234 D6W527 Q8TB72
|
| Accessions |
AAY15026 EAX00821 EAX00822 EAX00823 EAX00824 Q8TB72 AF272350 AAL36981 AF315591 AAG31806 AK093847 BAG52772 AK304198 BAG65078 BC024218 AAH24218 BC112046 AAI12047 BC112048 AAI12049 BC143550 AAI43551 BC143552 BG717417 BX641165 D87078 BAA19665 XM_005262607 XP_005262664 XM_005262609 XP_005262666 XM_005262610 XP_005262667 XM_006711973 XP_006712036 XM_006711974 XP_006712037 XM_006711975 XP_006712038 XM_011532719 XP_011531021 XM_011532720 XP_011531022 XM_011532721 XP_011531023 XM_011532722 XP_011531024 XM_011532723 XP_011531025 XM_011532724 XP_011531026 XM_011532725 XP_011531027 NM_001282752 NP_001269681 NM_001282790 NP_001269719 NM_001282791 NP_001269720 NM_015317 NP_056132
|
| Function |
Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. {ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22955276}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305|PubMed:19168546}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168546}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269|PubMed:12459267, ECO:0000269|PubMed:12511597, ECO:0000269|PubMed:19168546}.
|