| Gene Symbol |
OBFC1
|
| Entrez Gene |
79991
|
| Alt Symbol |
AAF-44, AAF44, RPA-32, STN1, bA541N10.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oligonucleotide/oligosaccharide-binding fold containing 1
|
| Other Description |
CST complex subunit STN1|alpha accessory factor 44|oligonucleotide/oligosaccharide-binding fold-containing protein 1|replication protein A 32 kDa subunit|suppressor of cdc thirteen homolog
|
| Swissprots |
D3DR99 Q5TCZ0 Q9H668
|
| Accessions |
EAW49619 EAW49620 Q9H668 AK026212 BAB15396 AK057720 BC017400 AAH17400 HG503231 HQ448216 ADQ32696 XM_006717976 XP_006718039 XM_011540184 XP_011538486 NM_024928 NP_079204
|
| Function |
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269|PubMed:19648609, ECO:0000269|PubMed:19854130}.
|
| Subcellular Location |
Nucleus. Chromosome, telomere.
|
![Western Blot: OBFC1 Overexpression Lysate (Adult Normal) [NBL1-13899] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OBFC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3861_OBFC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13899-img0002.jpg)