Gene Symbol | OBFC1 |
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Entrez Gene | 79991 |
Alt Symbol | AAF-44, AAF44, RPA-32, STN1, bA541N10.2 |
Species | Human |
Gene Type | protein-coding |
Description | oligonucleotide/oligosaccharide-binding fold containing 1 |
Other Description | CST complex subunit STN1|alpha accessory factor 44|oligonucleotide/oligosaccharide-binding fold-containing protein 1|replication protein A 32 kDa subunit|suppressor of cdc thirteen homolog |
Swissprots | D3DR99 Q5TCZ0 Q9H668 |
Accessions | EAW49619 EAW49620 Q9H668 AK026212 BAB15396 AK057720 BC017400 AAH17400 HG503231 HQ448216 ADQ32696 XM_006717976 XP_006718039 XM_011540184 XP_011538486 NM_024928 NP_079204 |
Function | Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269|PubMed:19648609, ECO:0000269|PubMed:19854130}. |
Subcellular Location | Nucleus. Chromosome, telomere. |
OBFC1 CRISPR/Cas9 KO Plasmid (h) - sc-405050 from Santa Cruz Biotechnology
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OBFC1 HDR Plasmid (h) - sc-405050-HDR from Santa Cruz Biotechnology
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OBFC1 Double Nickase Plasmid (h) - sc-405050-NIC from Santa Cruz Biotechnology
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OBFC1 Double Nickase Plasmid (h2) - sc-405050-NIC-2 from Santa Cruz Biotechnology
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OBFC1 CRISPR Activation Plasmid (h) - sc-405050-ACT from Santa Cruz Biotechnology
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OBFC1 CRISPR Activation Plasmid (h2) - sc-405050-ACT-2 from Santa Cruz Biotechnology
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OBFC1 Lentiviral Activation Particles (h) - sc-405050-LAC from Santa Cruz Biotechnology
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OBFC1 Lentiviral Activation Particles (h2) - sc-405050-LAC-2 from Santa Cruz Biotechnology
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OBFC1 siRNA (h) - sc-90707 from Santa Cruz Biotechnology
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OBFC1 shRNA Plasmid (h) - sc-90707-SH from Santa Cruz Biotechnology
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OBFC1 shRNA (h) Lentiviral Particles - sc-90707-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15671 from Sigma-Aldrich
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OBFC1 siRNA (Human) - CRJ2712 from Cohesion Biosciences
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OBFC1 RNAi - H00079991-R01 from Novus Biologicals
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Human OBFC1 siRNA - orb273213 from Biorbyt
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OBFC1 shRNA Plasmid (Human) - CHJ2712 from Cohesion Biosciences
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OBFC1 miRNA 3'UTR clone - MiUTR4H-TG06211 from Creative biogene
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