| Gene Symbol |
ANAPC4
|
| Entrez Gene |
29945
|
| Alt Symbol |
APC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anaphase promoting complex subunit 4
|
| Other Description |
anaphase-promoting complex subunit 4|cyclosome subunit 4
|
| Swissprots |
Q6PCC6 Q9UJX5 A8K8H1 Q9NSH6 E9PCR4
|
| Accessions |
EAW92839 EAW92840 Q9UJX5 AF191338 AAF05752 AK001881 AK023562 AK023597 BAG51209 AK292336 BAF85025 AL353932 CAB89245 AY429517 AY429518 BC059383 AAH59383 BI546948 CA312572 XM_005248159 XP_005248216 XM_011513838 XP_011512140 XM_011513839 XP_011512141 NM_001286756 NP_001273685 NM_013367 NP_037499
|
| Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.
|
| Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|