Gene Symbol | ANAPC4 |
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Entrez Gene | 29945 |
Alt Symbol | APC4 |
Species | Human |
Gene Type | protein-coding |
Description | anaphase promoting complex subunit 4 |
Other Description | anaphase-promoting complex subunit 4|cyclosome subunit 4 |
Swissprots | Q6PCC6 Q9UJX5 A8K8H1 Q9NSH6 E9PCR4 |
Accessions | EAW92839 EAW92840 Q9UJX5 AF191338 AAF05752 AK001881 AK023562 AK023597 BAG51209 AK292336 BAF85025 AL353932 CAB89245 AY429517 AY429518 BC059383 AAH59383 BI546948 CA312572 XM_005248159 XP_005248216 XM_011513838 XP_011512140 XM_011513839 XP_011512141 NM_001286756 NP_001273685 NM_013367 NP_037499 |
Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}. |
Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection |
APC4 CRISPR/Cas9 KO Plasmid (h) - sc-418010 from Santa Cruz Biotechnology
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APC4 HDR Plasmid (h) - sc-418010-HDR from Santa Cruz Biotechnology
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APC4 Double Nickase Plasmid (h) - sc-418010-NIC from Santa Cruz Biotechnology
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APC4 Double Nickase Plasmid (h2) - sc-418010-NIC-2 from Santa Cruz Biotechnology
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APC4 CRISPR Activation Plasmid (h) - sc-418010-ACT from Santa Cruz Biotechnology
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APC4 CRISPR Activation Plasmid (h2) - sc-418010-ACT-2 from Santa Cruz Biotechnology
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APC4 Lentiviral Activation Particles (h) - sc-418010-LAC from Santa Cruz Biotechnology
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APC4 Lentiviral Activation Particles (h2) - sc-418010-LAC-2 from Santa Cruz Biotechnology
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APC4 siRNA (h) - sc-29704 from Santa Cruz Biotechnology
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APC4 shRNA Plasmid (h) - sc-29704-SH from Santa Cruz Biotechnology
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APC4 shRNA (h) Lentiviral Particles - sc-29704-V from Santa Cruz Biotechnology
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Apc4 RNAi - H00029945-R01 from Novus Biologicals
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MISSION® esiRNA - EHU009831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3141 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01361 from Sigma-Aldrich
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ANAPC4 siRNA (Human) - CRH9287 from Cohesion Biosciences
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ANAPC4 - MBS8241373 from MyBioSource
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shRNA set against Human Anapc4 (NM_013367.2) - SHH236130 from Creative biogene
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shRNA set against Human ANAPC4(NM_013367.2) - SHG057355 from Creative biogene
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Human ANAPC4 siRNA - orb269789 from Biorbyt
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ANAPC4 shRNA Plasmid (Human) - CHH9287 from Cohesion Biosciences
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ANAPC4 miRNA 3'UTR clone - MiUTR1H-00357 from Creative biogene
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