| Gene Symbol | CYBB |
|---|---|
| Entrez Gene | 1536 |
| Alt Symbol | AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome b-245, beta polypeptide |
| Other Description | CGD91-phox|NADPH oxidase 2|cytochrome b(558) subunit beta|cytochrome b-245 heavy chain|cytochrome b558 subunit beta|heme-binding membrane glycoprotein gp91phox|neutrophil cytochrome b 91 kDa polypeptide|p22 phagocyte B-cytochrome|superoxide-generating NADPH oxidase heavy chain subunit |
| Swissprots | P04839 A8K138 Q2PP16 |
| Accessions | AAL76082 ABC40728 ABY87073 ADQ73898 BAA34183 CAA29327 EAW59453 P04839 AK289753 BAF82442 AK301476 BAG62993 AK301491 BAG63002 AK304033 BAG64947 AK312929 BC032720 AAH32720 DA995835 DQ890878 ABM81804 DQ894032 ABM84958 S67289 AAB29151 X04011 CAA27635 XM_011543890 XP_011542192 NM_000397 NP_000388 |
| Function | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Detected in neutrophils (at protein level). {ECO:0000269|PubMed:19028840}. |
| Top Pathways | Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation |