CYBB

Gene Symbol CYBB
Entrez Gene 1536
Alt Symbol AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX
Species Human
Gene Type protein-coding
Description cytochrome b-245, beta polypeptide
Other Description CGD91-phox|NADPH oxidase 2|cytochrome b(558) subunit beta|cytochrome b-245 heavy chain|cytochrome b558 subunit beta|heme-binding membrane glycoprotein gp91phox|neutrophil cytochrome b 91 kDa polypeptide|p22 phagocyte B-cytochrome|superoxide-generating NADPH oxidase heavy chain subunit
Swissprots P04839 A8K138 Q2PP16
Accessions AAL76082 ABC40728 ABY87073 ADQ73898 BAA34183 CAA29327 EAW59453 P04839 AK289753 BAF82442 AK301476 BAG62993 AK301491 BAG63002 AK304033 BAG64947 AK312929 BC032720 AAH32720 DA995835 DQ890878 ABM81804 DQ894032 ABM84958 S67289 AAB29151 X04011 CAA27635 XM_011543890 XP_011542192 NM_000397 NP_000388
Function Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Detected in neutrophils (at protein level). {ECO:0000269|PubMed:19028840}.
Top Pathways Leukocyte transendothelial migration, Phagosome, Osteoclast differentiation

gp91-phox CRISPR/Cas9 KO Plasmid (h) - sc-400222 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox HDR Plasmid (h) - sc-400222-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox Double Nickase Plasmid (h) - sc-400222-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox Double Nickase Plasmid (h2) - sc-400222-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox CRISPR Activation Plasmid (h) - sc-400222-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox CRISPR Activation Plasmid (h2) - sc-400222-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox Lentiviral Activation Particles (h) - sc-400222-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox Lentiviral Activation Particles (h2) - sc-400222-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp91-phox siRNA (h) - sc-35503 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp91-phox shRNA Plasmid (h) - sc-35503-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp91-phox shRNA (h) Lentiviral Particles - sc-35503-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp91-phox siRNA (h2) - sc-44302 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp91-phox shRNA Plasmid (h2) - sc-44302-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp91-phox shRNA (h2) Lentiviral Particles - sc-44302-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYBB/NOX2 RNAi - H00001536-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU010941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1241 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1241 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CYBB siRNA (Human) - CRH1085 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYBB - MBS8207793 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human CYBB siRNA - orb261587 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYBB shRNA Plasmid (Human) - CHH1085 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
Search more