DGKZ

Gene Symbol DGKZ
Entrez Gene 8525
Alt Symbol DAGK5, DAGK6, DGK-ZETA, hDGKzeta
Species Human
Gene Type protein-coding
Description diacylglycerol kinase, zeta
Other Description DAG kinase zeta|diacylglycerol kinase zeta|diacylglycerol kinase, zeta 104kDa|diglyceride kinase zeta
Swissprots O00542 J3KNJ6 G3V0F6 E9PPW4 B7Z2M9 Q6ZVG7 B7Z6M3 Q8IVW9 F6UCU9 Q13574
Accessions EAW68006 EAW68007 EAW68008 EAW68009 Q13574 AB209635 BAD92872 AK097960 AK123378 BAC85599 AK124594 BAC85894 AK124693 AK126970 BAC86770 AK225774 AK293615 BAH11548 AK294888 BAH11915 AK300577 BAH13309 AK303322 BAH13942 AK312398 BC008018 AAH08018 BC041770 AAH41770 BU849628 BX370257 BX648433 BX649190 CAE46208 CB959911 DC416889 U51477 AAC50478 U94905 AAB60859 XM_005253181 XP_005253238 XM_005253182 XP_005253239 XM_006718354 XP_006718417 XM_006718355 XP_006718418 XM_011520421 XP_011518723 XM_011520422 XP_011518724 XM_011520423 XP_011518725 XR_930918 NM_001105540 NP_001099010 NM_001199266 NP_001186195 NM_001199267 NP_001186196 NM_003646 NP_003637 NM_201532 NP_963290 NM_201533 NP_963291 NM_001199268 NP_001186197
Function Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. {ECO:0000269|PubMed:11257115}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane.
Tissue Specificity Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
Top Pathways Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system

DGK-ζ (C-19) - sc-8722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DGK-ζ (C-19): sc-8722. Western blot analysis of DGK-ζ expression in non-transfected: sc-117752 (A) and mouse DGK-ζ transfected: sc-126726 (B) 293T whole cell lysates.

DGK-ζ (N-19) - sc-8721 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DGK-ζ (N-19): sc-8721. Western blot analysis of DGK-ζ expression in non-transfected: sc-117752 (A) and mouse DGK-ζ transfected: sc-126726 (B) 293T whole cell lysates.

Anti-DGKZ antibody - ab111047 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111047 at 1/50 dilution staining DGKZ in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-DGKZ antibody - ab67791 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DGKZ antibody (ab67791) at 1/500 dilutionLane 1 : DGKZ transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-DGKZ Antibody (aa800-945) - LS-C128601 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026, APC) - LS-C222078 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026, AP) - LS-C222077 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026, Biotin) - LS-C222080 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026, FITC) - LS-C222081 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026, PE) - LS-C222084 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026, Azide-free, HRP) - LS-C222082 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa695-932, Biotin) - LS-C301087 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa695-932, FITC) - LS-C304007 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody - LS-C307234 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DGKZ Antibody - LS-C310120 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa997-1026) - LS-C329466 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGKZ Antibody (aa695-932) - LS-C293683 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant DGKZ.

Anti-DGKZ Antibody (aa601-650) IHC-plus™ - LS-B8416 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DGKZ antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8416 dilution 5 ug/ml.

Anti-DGKZ Antibody (aa989-1019) - LS-C101153 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-DGKZ Antibody (aa1067-1117) - LS-C289672 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DGK zeta by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-DGK zeta used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

DGK-zeta Antibody [Unconjugated] - AF6099 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of Ramos human Burkitt's lymphoma cell line and K562 human chronic myelogenous leukemia cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human DGK‑ zeta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6099) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). Specific bands were detected for DGK‑ zeta at approximately 124 & 114 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

DGK-zeta Antibody - NBP2-13918 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DGK-zeta Antibody [NBP2-13918] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

DGK-zeta Antibody - NBP2-29920 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DGK-zeta Antibody [NBP2-29920] - DGKZ (arrow) using DGKZ Antibody (C-term) (NBP2-29920 ). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DGKZ

DGK-zeta Antibody - H00008525-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: DGK-zeta Antibody [H00008525-B01] - DGKZ Antibody [H00008525-B01] - analysis of DGKZ expression in transfected 293T cell line by DGKZ MaxPab polyclonal antibody (B01). Lane 1: DGKZ transfected lysate (104.10 KDa). Lane 2: Non-transfected lysate.

DGK-zeta Antibody - H00008525-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: DGK-zeta Antibody [H00008525-B01P] - Analysis of DGKZ expression in transfected 293T cell line by DGKZ polyclonal antibody. Lane 1: DGKZ transfected lysate(102.19 KDa). Lane 2: Non-transfected lysate.
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