| Gene Symbol |
DGKZ
|
| Entrez Gene |
8525
|
| Alt Symbol |
DAGK5, DAGK6, DGK-ZETA, hDGKzeta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diacylglycerol kinase, zeta
|
| Other Description |
DAG kinase zeta|diacylglycerol kinase zeta|diacylglycerol kinase, zeta 104kDa|diglyceride kinase zeta
|
| Swissprots |
O00542 J3KNJ6 G3V0F6 E9PPW4 B7Z2M9 Q6ZVG7 B7Z6M3 Q8IVW9 F6UCU9 Q13574
|
| Accessions |
EAW68006 EAW68007 EAW68008 EAW68009 Q13574 AB209635 BAD92872 AK097960 AK123378 BAC85599 AK124594 BAC85894 AK124693 AK126970 BAC86770 AK225774 AK293615 BAH11548 AK294888 BAH11915 AK300577 BAH13309 AK303322 BAH13942 AK312398 BC008018 AAH08018 BC041770 AAH41770 BU849628 BX370257 BX648433 BX649190 CAE46208 CB959911 DC416889 U51477 AAC50478 U94905 AAB60859 XM_005253181 XP_005253238 XM_005253182 XP_005253239 XM_006718354 XP_006718417 XM_006718355 XP_006718418 XM_011520421 XP_011518723 XM_011520422 XP_011518724 XM_011520423 XP_011518725 XR_930918 NM_001105540 NP_001099010 NM_001199266 NP_001186195 NM_001199267 NP_001186196 NM_003646 NP_003637 NM_201532 NP_963290 NM_201533 NP_963291 NM_001199268 NP_001186197
|
| Function |
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. {ECO:0000269|PubMed:11257115}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cell membrane.
|
| Tissue Specificity |
Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
|
| Top Pathways |
Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system
|