Gene Symbol | TNF |
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Entrez Gene | 443540 |
Alt Symbol | TNF-alpha |
Species | Sheep |
Gene Type | protein-coding |
Description | tumor necrosis factor |
Other Description | TNF-a|cachectin|tumor necrosis factor (TNF superfamily, member 2)|tumor necrosis factor alpha|tumor necrosis factor ligand superfamily member 2 |
Swissprots | P23383 |
Accessions | AAS91697 AAS91698 AAS91699 ABR01166 P23383 AY289202 AAP43688 DQ153000 ABB02332 X55152 CAA38952 X55966 CAA39437 X56756 CAA40076 XM_012100437 XP_011955827 NM_001024860 NP_001020031 |
Function | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. |
Subcellular Location | C-domain 2: Secreted {ECO:0000250}. |
Top Pathways | Sphingolipid signaling pathway, Proteoglycans in cancer, Cytokine-cytokine receptor interaction, Allograft rejection, RIG-I-like receptor signaling pathway |
Tumor necrosis factor Antibody - abx110668 from Abbexa
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Tumor necrosis factor Antibody (Biotin) - abx106402 from Abbexa
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Tumor necrosis factor Antibody (FITC) - abx107814 from Abbexa
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Tumor necrosis factor Antibody (HRP) - abx109231 from Abbexa
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Anti-Tumor Necrosis Factor Alpha (TNFa) - 20-2319 from ARP American Research Products
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TNF ALPHA, Monoclonal Antibody - MBS219873 from MyBioSource
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TNF ALPHA, Monoclonal Antibody - MBS219893 from MyBioSource
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Tumor necrosis factor, Polyclonal Antibody - MBS1488369 from MyBioSource
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Tumor necrosis factor, Polyclonal Antibody - MBS1489531 from MyBioSource
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Tumor necrosis factor, Polyclonal Antibody - MBS1490337 from MyBioSource
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Tumor Necrosis Factor Alpha (TNFa), Polyclonal Antibody - MBS2016518 from MyBioSource
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Tumor Necrosis Factor Alpha (TNFa), Polyclonal Antibody - MBS2004318 from MyBioSource
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Tumor Necrosis Factor Alpha (TNFa), Polyclonal Antibody - MBS2005984 from MyBioSource
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TNF Alpha Antibody | VPM61 - MCA905GA from AbD Serotec
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TNF Alpha Antibody | VPM62 - MCA906GA from AbD Serotec
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TNF Antibody,Biotin conjugated - CSB-PA023955DD01SH from Cusabio
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TNF Antibody - CSB-PA023955DA01SH from Cusabio
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TNF Antibody,HRP conjugated - CSB-PA023955DB01SH from Cusabio
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TNF Antibody,FITC conjugated - CSB-PA023955DC01SH from Cusabio
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Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) - MAA133Ov21 from Cloud-clone
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Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) - PAA133Ov01 from Cloud-clone
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Biotin-Linked Antibody to Tumor Necrosis Factor Alpha (TNFa) - PAA133Ov71 from Cloud-clone
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Tumor Necrosis Factor Alpha, Monoclonal Antibody - MBS2025729 from MyBioSource
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Tumor necrosis factor antibody (HRP) - orb241357 from Biorbyt
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Tumor Necrosis Factor Alpha (TNFa) Monoclonal Antibody - CAU29197 from Biomatik
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