Gene Symbol | TNF |
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Entrez Gene | 443540 |
Alt Symbol | TNF-alpha |
Species | Sheep |
Gene Type | protein-coding |
Description | tumor necrosis factor |
Other Description | TNF-a|cachectin|tumor necrosis factor (TNF superfamily, member 2)|tumor necrosis factor alpha|tumor necrosis factor ligand superfamily member 2 |
Swissprots | P23383 |
Accessions | AAS91697 AAS91698 AAS91699 ABR01166 P23383 AY289202 AAP43688 DQ153000 ABB02332 X55152 CAA38952 X55966 CAA39437 X56756 CAA40076 XM_012100437 XP_011955827 NM_001024860 NP_001020031 |
Function | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. |
Subcellular Location | C-domain 2: Secreted {ECO:0000250}. |
Top Pathways | Sphingolipid signaling pathway, Proteoglycans in cancer, Cytokine-cytokine receptor interaction, Allograft rejection, RIG-I-like receptor signaling pathway |
Sheep TNF protein - orb244596 from Biorbyt
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Sheep TNF protein - orb246019 from Biorbyt
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Sheep TNFa Protein - abx069532 from Abbexa
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Tumor Necrosis Factor Alpha (TNFa), Sheep - 20-6320 from ARP American Research Products
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Recombinant Tumor Necrosis Factor Alpha (TNFa) - RPA133Ov01 from Cloud-clone
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Recombinant sheep Tumor necrosis factor - CSB-YP023975SH CSB-BP023975SH CSB-MP023975SH from Cusabio
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Recombinant sheep Tumor necrosis factor - CSB-EP023975SH from Cusabio
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Recombinant Sheep Tumor necrosis factor(TNF) - CSB-YP023955SH CSB-EP023955SH CSB-BP023955SH CSB-MP023955SH from Cusabio
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Tumor Necrosis Factor Alpha (TNFa) - RPU144223 from Biomatik
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TNF Recombinant Protein (OPCA01905) - OPCA01905 from Aviva Systems Biology
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TNF Recombinant Protein (OPCA02817) - OPCA02817 from Aviva Systems Biology
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Sheep TNF protein - orb358262 from Biorbyt
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Recombinant Tumor Necrosis Factor Alpha (TNFa) - RPU44223 from Biomatik
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TNF Recombinant Protein (OPCD07540) - OPCD07540 from Aviva Systems Biology
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Recombinant sheep Tumor necrosis factor - AP70864 from Signalway Antibody
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Recombinant sheep Tumor necrosis factor - AP72820 from Signalway Antibody
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Sheep TNF protein - orb358129 from Biorbyt
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