Gene Symbol | TNPO3 |
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Entrez Gene | 23534 |
Alt Symbol | IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2, TRNSR |
Species | Human |
Gene Type | protein-coding |
Description | transportin 3 |
Other Description | imp12|importin 12|limb girdle muscular dystrophy 1F (autosomal dominant)|transportin-3|transportin-SR |
Swissprots | C9IZM0 Q9Y3R2 Q6NUM1 A4D1K9 Q9Y5L0 Q96GU9 Q96G71 |
Accessions | EAL24106 EAW83708 EAW83709 EAW83710 Q9Y5L0 AF145029 AAD38537 AJ133769 CAB42643 AK001263 BAG50881 AK022910 BAG51133 AK225999 AK312580 BAG35474 AW051835 BC009221 AAH09221 BC009923 BC068530 BC156517 AAI56518 BC172512 AAI72512 BQ774864 CB992781 DA188633 DA720844 DA773316 XM_011515989 XP_011514291 NM_001191028 NP_001177957 NM_012470 NP_036602 NR_034053 |
Function | Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. {ECO:0000269|PubMed:10366588, ECO:0000269|PubMed:10713112, ECO:0000269|PubMed:11517331, ECO:0000269|PubMed:12628928}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10713112}. Nucleus {ECO:0000269|PubMed:10713112}. |
Tissue Specificity | Expressed in skeletal muscle. {ECO:0000269|PubMed:23667635}. |
Importin-12 CRISPR/Cas9 KO Plasmid (h) - sc-405818 from Santa Cruz Biotechnology
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Importin-12 HDR Plasmid (h) - sc-405818-HDR from Santa Cruz Biotechnology
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Importin-12 Double Nickase Plasmid (h) - sc-405818-NIC from Santa Cruz Biotechnology
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Importin-12 Double Nickase Plasmid (h2) - sc-405818-NIC-2 from Santa Cruz Biotechnology
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Importin-12 CRISPR Activation Plasmid (h) - sc-405818-ACT from Santa Cruz Biotechnology
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Importin-12 CRISPR Activation Plasmid (h2) - sc-405818-ACT-2 from Santa Cruz Biotechnology
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Importin-12 Lentiviral Activation Particles (h) - sc-405818-LAC from Santa Cruz Biotechnology
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Importin-12 Lentiviral Activation Particles (h2) - sc-405818-LAC-2 from Santa Cruz Biotechnology
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Importin-12 siRNA (h) - sc-89750 from Santa Cruz Biotechnology
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Importin-12 shRNA Plasmid (h) - sc-89750-SH from Santa Cruz Biotechnology
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Importin-12 shRNA (h) Lentiviral Particles - sc-89750-V from Santa Cruz Biotechnology
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TNPO3 RNAi - H00023534-R02 from Novus Biologicals
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MISSION® esiRNA - EHU158031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21795 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05275 from Sigma-Aldrich
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TNPO3 siRNA (Human) - CRH8339 from Cohesion Biosciences
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TNPO3 - MBS8238625 from MyBioSource
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shRNA set against Human TNPO3 (NM_012470.3) - SHH432500 from Creative biogene
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shRNA set against Human TNPO3(NM_012470.3) - SHL043222 from Creative biogene
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Human TNPO3 siRNA - orb268841 from Biorbyt
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TNPO3 shRNA Plasmid (Human) - CHH8339 from Cohesion Biosciences
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TNPO3 miRNA 3'UTR clone - MiUTR1H-10628 from Creative biogene
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