| Gene Symbol |
Usp15
|
| Entrez Gene |
14479
|
| Alt Symbol |
4921514G19Rik, AI327321, E430033I05Rik, Gcap18
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 15
|
| Other Description |
deubiquitinating enzyme 15|granule cell antiserum positive 18|ubiquitin carboxyl-terminal hydrolase 15|ubiquitin thioesterase 15|ubiquitin thiolesterase 15|ubiquitin-specific-processing protease 15
|
| Swissprots |
Q80TY6 Q3UL25 Q80UK9 Q3TGF5 Q3UZH0 Q3TTB2 Q8R5H1
|
| Accessions |
EDL24439 EDL24440 EDL24441 Q8R5H1 AF468037 AAL77418 AK014891 AK046332 BAC32683 AK052398 AK083303 BAC38854 AK084098 AK088515 AK088952 AK122301 BAC65583 AK133852 BAE21887 AK145749 BAE26626 AK161469 BAE36413 AK161771 BAE36566 AK161957 AK163284 BAE37275 AK163315 AK164382 BAE37763 AK168755 BAE40593 AK192688 AK202182 AK216706 AW490591 BB843959 BB857893 BC003978 BC050042 AAH50042 DQ695348 L10903 XM_006513225 XP_006513288 XM_006513226 XP_006513289 XM_006513227 XP_006513290 XM_006513228 XP_006513291 XR_380365 NM_001301628 NP_001288557 NM_027604 NP_081880
|
| Function |
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an associated component of COP9 signalosome complex (CSN) and regulates dif
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in testis, heart and liver. {ECO:0000269|PubMed:12532266}.
|