Usp15

Gene Symbol Usp15
Entrez Gene 14479
Alt Symbol 4921514G19Rik, AI327321, E430033I05Rik, Gcap18
Species Mouse
Gene Type protein-coding
Description ubiquitin specific peptidase 15
Other Description deubiquitinating enzyme 15|granule cell antiserum positive 18|ubiquitin carboxyl-terminal hydrolase 15|ubiquitin thioesterase 15|ubiquitin thiolesterase 15|ubiquitin-specific-processing protease 15
Swissprots Q80TY6 Q3UL25 Q80UK9 Q3TGF5 Q3UZH0 Q3TTB2 Q8R5H1
Accessions EDL24439 EDL24440 EDL24441 Q8R5H1 AF468037 AAL77418 AK014891 AK046332 BAC32683 AK052398 AK083303 BAC38854 AK084098 AK088515 AK088952 AK122301 BAC65583 AK133852 BAE21887 AK145749 BAE26626 AK161469 BAE36413 AK161771 BAE36566 AK161957 AK163284 BAE37275 AK163315 AK164382 BAE37763 AK168755 BAE40593 AK192688 AK202182 AK216706 AW490591 BB843959 BB857893 BC003978 BC050042 AAH50042 DQ695348 L10903 XM_006513225 XP_006513288 XM_006513226 XP_006513289 XM_006513227 XP_006513290 XM_006513228 XP_006513291 XR_380365 NM_001301628 NP_001288557 NM_027604 NP_081880
Function Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an associated component of COP9 signalosome complex (CSN) and regulates dif
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in testis, heart and liver. {ECO:0000269|PubMed:12532266}.

USP15 CRISPR/Cas9 KO Plasmid (m) - sc-420505 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 HDR Plasmid (m) - sc-420505-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 Double Nickase Plasmid (m) - sc-420505-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 Double Nickase Plasmid (m2) - sc-420505-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 CRISPR Activation Plasmid (m) - sc-420505-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 CRISPR Activation Plasmid (m2) - sc-420505-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 Lentiviral Activation Particles (m) - sc-420505-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 Lentiviral Activation Particles (m2) - sc-420505-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

USP15 siRNA (m) - sc-76820 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

USP15 shRNA Plasmid (m) - sc-76820-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

USP15 shRNA (m) Lentiviral Particles - sc-76820-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU023921 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN43999 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43999 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

USP15 siRNA (Mouse) - CRM1510 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

USP15 - MBS8238448 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse USP15 (NM_027604.3) - SHH441276 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Usp15(NM_027604.3) - SHL117306 from Creative biogene

Category siRNA
Species Reactivities Mouse

USP15 shRNA Plasmid (Mouse) - CHM1510 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

USP15 miRNA 3'UTR clone - MiUTR1M-12502 from Creative biogene

Species Reactivities Mouse
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