| Gene Symbol |
MIF
|
| Entrez Gene |
100857237
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
|
| Other Description |
L-dopachrome isomerase|L-dopachrome tautomerase|Phenylpyruvate tautomerase|macrophage migration inhibitory factor
|
| Swissprots |
Q02960
|
| Accessions |
Q02960 AL585053 BU431911 M95776 AAA48939 XM_003642234 XP_003642282 NM_001305091 NP_001292020
|
| Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial antigens (By similarity). {ECO:0000250}.
|
| Top Pathways |
Tyrosine metabolism, Phenylalanine metabolism
|