| Gene Symbol |
EDARADD
|
| Entrez Gene |
128178
|
| Alt Symbol |
ECTD11A, ECTD11B, ED3, EDA3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EDAR-associated death domain
|
| Other Description |
EDAR-associated death domain protein|crinkled homolog|ectodysplasia A receptor associated death domain|ectodysplasin A receptor associated adapter protein|ectodysplasin-A receptor-associated adapter protein
|
| Swissprots |
B1AL54 B9ZVW5 A8K7B5 Q5VYJ7 A2VCK5 Q8WWZ3
|
| Accessions |
AAK40285 AAK40286 AER00472 EAW70047 EAW70048 EAW70049 EAW70050 EAW70051 EAW70052 Q8WWZ3 AK096339 AK290862 BAF83551 AK291930 BAF84619 AK314634 BAG37197 AY028913 AAK40287 AY028914 AAK40288 AY071862 AAL60590 BC006533 BC046928 BC114557 BC114560 BC128082 AAI28083 NM_080738 NP_542776 NM_145861 NP_665860
|
| Function |
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF- kappa-B. {ECO:0000269|PubMed:11882293}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.
|