| Gene Symbol |
CAV1
|
| Entrez Gene |
403980
|
| Alt Symbol |
caveolin 1
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
caveolin 1, caveolae protein, 22kDa
|
| Other Description |
caveolin-1|vesicular integral-membrane protein VIP21
|
| Swissprots |
P33724 A0M8U8
|
| Accessions |
AAR16266 CAA78151 P33724 U47060 AAA87050 XM_005628347 XP_005628404 NM_001003296 NP_001003296
|
| Function |
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
|
| Subcellular Location |
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts (By similarity). Potential hairpin-like structure in the membrane. Membrane protein of caveolae. {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer
|
