| Gene Symbol |
NLRP12
|
| Entrez Gene |
91662
|
| Alt Symbol |
CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NLR family, pyrin domain containing 12
|
| Other Description |
NACHT, LRR and PYD domains-containing protein 12|PYRIN-containing APAF1-like protein 7|monarch 1|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12|regulated by nitric oxide
|
| Swissprots |
B3KTE7 Q9BY26 A8MTQ2 Q8NEU4 P59046
|
| Accessions |
EAW72151 EAW72152 EAW72153 EAW72154 EAW72155 EAW72156 EAW72157 P59046 AF231021 AAK14942 AK095460 BAG53059 AK290772 BAF83461 AY095146 AAM18227 AY116204 AAM75142 AY116205 AAM75143 AY116206 AAM75144 AY116207 AAM75145 AY154467 AAO18163 BC028069 AAH28069 DA619102 DQ891084 ABM82010 DQ894266 ABM85192 XM_011527478 XP_011525780 XM_011527479 XP_011525781 XM_011527480 XP_011525782 XM_011527481 XP_011525783 XM_011527482 XP_011525784 XM_011527483 XP_011525785 NM_001277126 NP_001264055 NM_001277129 NP_001264058 NM_144687 NP_653288 NM_033297
|
| Function |
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes. {ECO:0000269|PubMed:11167794}.
|