Trpa1

Gene Symbol Trpa1
Entrez Gene 312896
Alt Symbol Anktm1
Species Rat
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily A, member 1
Other Description ankyrin-like with transmembrane domains protein 1|transient receptor potential cation channel subfamily A member 1
Swissprots Q6RI86
Accessions EDM11520 Q6RI86 AY496961 AAS78661 NM_207608 NP_997491
Function Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Specifically expressed in a subset of nociceptive neurons. Expressed in dorsal root ganglia. {ECO:0000269|PubMed:12654248}.
Top Pathways Inflammatory mediator regulation of TRP channels

TRPA1 Antibody - NB100-98841 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: TRPA1 Antibody [NB100-98841] - IF on vagal nodose ganglia. Image from verified customer review.

TRPA1 Antibody - NB100-91319 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TRPA1 Antibody [NB100-91319] - WB on mouse brain lysate using Rabbit antibody to TRPA1 at 1 : 1000 dilution incubated overnight at 4C lysate should be prepared in RIPA with 1% Triton X-100 and no SDS/SDC).

TRPA1 Antibody - abx116195 from Abbexa

Host Rabbit
Clonality Polyclonal

Rabbit Anti-Rat TRPA1 - 114-10136 from RayBiotech

Host Rabbit

TRPA1 Antibody - CSB-PA025074GA01HU from Cusabio

Host Rabbit
Search more