| Gene Symbol |
Trpa1
|
| Entrez Gene |
312896
|
| Alt Symbol |
Anktm1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily A, member 1
|
| Other Description |
ankyrin-like with transmembrane domains protein 1|transient receptor potential cation channel subfamily A member 1
|
| Swissprots |
Q6RI86
|
| Accessions |
EDM11520 Q6RI86 AY496961 AAS78661 NM_207608 NP_997491
|
| Function |
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Specifically expressed in a subset of nociceptive neurons. Expressed in dorsal root ganglia. {ECO:0000269|PubMed:12654248}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|