| Gene Symbol |
FEN1
|
| Entrez Gene |
100307042
|
| Alt Symbol |
FEN-1
|
| Species |
Sheep
|
| Gene Type |
protein-coding
|
| Description |
flap structure-specific endonuclease 1
|
| Other Description |
FEN-1|flap endonuclease 1
|
| Swissprots |
C8BKD0
|
| Accessions |
C8BKD0 GQ221048 ACV04829 XM_012101530 XP_011956920 XM_012101531 XP_011956921 XM_012101532 XP_011956922 XM_012101533 XP_011956923 XM_012101534 XP_011956924 NM_001166196 NP_001159668
|
| Function |
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000255|HAMAP- Rule:MF_03140}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140}. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. {ECO:0000255|HAMAP-Rule:MF_03140}.
|
| Top Pathways |
DNA replication, Base excision repair, Non-homologous end-joining
|