| Gene Symbol | FEN1 |
|---|---|
| Entrez Gene | 100307042 |
| Alt Symbol | FEN-1 |
| Species | Sheep |
| Gene Type | protein-coding |
| Description | flap structure-specific endonuclease 1 |
| Other Description | FEN-1|flap endonuclease 1 |
| Swissprots | C8BKD0 |
| Accessions | C8BKD0 GQ221048 ACV04829 XM_012101530 XP_011956920 XM_012101531 XP_011956921 XM_012101532 XP_011956922 XM_012101533 XP_011956923 XM_012101534 XP_011956924 NM_001166196 NP_001159668 |
| Function | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000255|HAMAP- Rule:MF_03140}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140}. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. {ECO:0000255|HAMAP-Rule:MF_03140}. |
| Top Pathways | DNA replication, Base excision repair, Non-homologous end-joining |
Recombinant Sheep Flap endonuclease 1(FEN1) - CSB-YP008585SH CSB-EP008585SH CSB-BP008585SH CSB-MP008585SH from Cusabio
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Flap endonuclease 1 (FEN1), Recombinant Protein - MBS1183901 from MyBioSource
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