| Gene Symbol |
IL1B
|
| Entrez Gene |
100034237
|
| Alt Symbol |
IL-1B
|
| Species |
Horse
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1, beta
|
| Other Description |
IL-1 beta|interleukin-1 beta
|
| Swissprots |
O77744 O18995 Q28386
|
| Accessions |
Q28386 D42147 BAA07718 D42165 BAA22528 EU438767 ABZ91976 U92481 AAC39256 NM_001082526 NP_001075995
|
| Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
|
| Top Pathways |
Tuberculosis, Salmonella infection, MAPK signaling pathway, Herpes simplex infection, Legionellosis
|
