| Gene Symbol |
KRTAP2-4
|
| Entrez Gene |
85294
|
| Alt Symbol |
KAP2.1B, KAP2.4, KRTAP2.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 2-4
|
| Other Description |
high sulfur keratin-associated protein 2.4|keratin associated protein 2.1B|keratin-associated protein 2-4|keratin-associated protein 2.4
|
| Swissprots |
Q495J2 Q9BYR9 P0C7H8
|
| Accessions |
EAW60703 Q9BYR9 AJ406930 CAC27569 BC101147 AAI01148 BC101148 AAI01149 BC101149 AAI01150 NM_033184 NP_149440
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed specifically in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269|PubMed:11279113}.
|