Gene Symbol | KRTAP2-4 |
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Entrez Gene | 85294 |
Alt Symbol | KAP2.1B, KAP2.4, KRTAP2.4 |
Species | Human |
Gene Type | protein-coding |
Description | keratin associated protein 2-4 |
Other Description | high sulfur keratin-associated protein 2.4|keratin associated protein 2.1B|keratin-associated protein 2-4|keratin-associated protein 2.4 |
Swissprots | Q495J2 Q9BYR9 P0C7H8 |
Accessions | EAW60703 Q9BYR9 AJ406930 CAC27569 BC101147 AAI01148 BC101148 AAI01149 BC101149 AAI01150 NM_033184 NP_149440 |
Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed specifically in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269|PubMed:11279113}. |
KRTAP2-4 CRISPR/Cas9 KO Plasmid (h) - sc-416681 from Santa Cruz Biotechnology
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KRTAP2-4 HDR Plasmid (h) - sc-416681-HDR from Santa Cruz Biotechnology
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KRTAP2-4 Double Nickase Plasmid (h) - sc-416681-NIC from Santa Cruz Biotechnology
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KRTAP2-4 Double Nickase Plasmid (h2) - sc-416681-NIC-2 from Santa Cruz Biotechnology
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KRTAP2-4 CRISPR Activation Plasmid (h) - sc-416681-ACT from Santa Cruz Biotechnology
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KRTAP2-4 CRISPR Activation Plasmid (h2) - sc-416681-ACT-2 from Santa Cruz Biotechnology
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KRTAP2-4 Lentiviral Activation Particles (h) - sc-416681-LAC from Santa Cruz Biotechnology
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KRTAP2-4 Lentiviral Activation Particles (h2) - sc-416681-LAC-2 from Santa Cruz Biotechnology
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KRTAP2-4 siRNA (h) - sc-93667 from Santa Cruz Biotechnology
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KRTAP2-4 shRNA Plasmid (h) - sc-93667-SH from Santa Cruz Biotechnology
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KRTAP2-4 shRNA (h) Lentiviral Particles - sc-93667-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11461 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02586 from Sigma-Aldrich
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KRTAP2-4 siRNA (Human) - CRJ3771 from Cohesion Biosciences
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Human KRTAP2-4 siRNA - orb274272 from Biorbyt
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KRTAP2-4 shRNA Plasmid (Human) - CHJ3771 from Cohesion Biosciences
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