| Gene Symbol |
Hs6st1
|
| Entrez Gene |
100689173
|
| Alt Symbol |
6OST1, HS6ST-1
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate 6-O-sulfotransferase 1
|
| Other Description |
Heparan-sulfate 6-O-sulfotransferase 1|heparan sulfate 6-sulfotransferase
|
| Swissprots |
Q91ZB4 O70158
|
| Accessions |
Q91ZB4 AB006180 BAA25761 JI885920 XM_007625908 XP_007624098 XM_007628911 XP_007627101
|
| Function |
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Also transfers sulfate to CDSNS-heparin and performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact). Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:11551899, ECO:0000269|PubMed:7876170}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|