Gene Symbol | Hs6st1 |
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Entrez Gene | 100689173 |
Alt Symbol | 6OST1, HS6ST-1 |
Species | Hamster |
Gene Type | protein-coding |
Description | heparan sulfate 6-O-sulfotransferase 1 |
Other Description | Heparan-sulfate 6-O-sulfotransferase 1|heparan sulfate 6-sulfotransferase |
Swissprots | Q91ZB4 O70158 |
Accessions | Q91ZB4 AB006180 BAA25761 JI885920 XM_007625908 XP_007624098 XM_007628911 XP_007627101 |
Function | 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Also transfers sulfate to CDSNS-heparin and performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact). Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:11551899, ECO:0000269|PubMed:7876170}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
Recombinant Cricetulus griseus Heparan-sulfate 6-O-sulfotransferase 1(HS6ST1) - CSB-YP821028DXU CSB-EP821028DXU CSB-BP821028DXU CSB-MP821028DXU from Cusabio
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Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1), Recombinant Protein - MBS1369404 from MyBioSource
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