| Gene Symbol | CARD8 |
|---|---|
| Entrez Gene | 22900 |
| Alt Symbol | CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN |
| Species | Human |
| Gene Type | protein-coding |
| Description | caspase recruitment domain family, member 8 |
| Other Description | CARD inhibitor of NF-kappaB-activating ligands|apoptotic protein NDPP1|caspase recruitment domain-containing protein 8|tumor up-regulated CARD-containing antagonist of CASP9|tumor up-regulated CARD-containing antagonist of caspase nine |
| Swissprots | B7Z496 E9PEM7 Q6PGP8 Q9Y2G2 Q96P82 B5KVR6 G3XAM9 B7Z4A2 |
| Accessions | CAC34902 EAW52319 EAW52320 EAW52321 EAW52322 EAW52323 EAW52324 EAW52325 Q9Y2G2 AB023172 BAA76799 AF143869 AF322184 AAG50014 AF331519 AAK01126 AF405558 AAL02427 AF511652 AAM46959 AI040349 AK094933 AK297045 BAH12482 AK297069 BAH12488 AK302327 BAH13675 AK311077 AK311079 AY026322 AAK08982 BC034564 BC041697 BC045539 AAH45539 BC046136 BC056891 AAH56891 BX641091 CAE46043 BX648568 CA448628 CB119078 DC404273 EU118120 ABW96891 EU118121 ABW96892 EU118122 ABW96893 XM_006723091 XP_006723154 XM_006723092 XP_006723155 XM_006723093 XP_006723156 XM_006723094 XP_006723157 XM_006723095 XP_006723158 XM_006723096 XP_006723159 XM_006723097 XP_006723160 XM_006723098 XP_006723161 XM_006723099 XP_006723162 XM_006723101 XP_006723164 XM_006723102 XP_006723165 XM_006723103 XP_006723166 XM_006723104 XP_006723167 XM_006723106 XP_006723169 XM_006723107 XP_006723170 XM_006723109 XP_006723172 XM_006723110 XP_006723173 XM_011526641 XP_011524943 XM_011526642 XP_011524944 XM_011526643 XP_011524945 XM_011526644 XP_011524946 XM_011526645 XP_011524947 XM_011526646 XP_011524948 XM_011526647 XP_011524949 XM_011526648 XP_011524950 XM_011526649 XP_011524951 XM_011526650 XP_011524952 XM_011526651 XP_011524953 XM_011526652 XP_011524954 XM_011526653 XP_011524955 XR_430193 XR_935766 XR_935767 XR_935768 XR_935769 XR_935770 XR_935771 XR_935772 XR_935773 XR_935774 NM_001184900 NP_001171829 NM_001184901 NP_001171830 NM_001184902 NP_001171831 NM_001184903 NP_001171832 NM_001184904 NP_001171833 NM_014959 NP_055774 NR_033678 NR_033679 NR_033680 |
| Function | Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15030775}. Nucleus {ECO:0000269|PubMed:15030775}. |
| Tissue Specificity | High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow. |
| Top Pathways | NOD-like receptor signaling pathway |