CARD8

Gene Symbol CARD8
Entrez Gene 22900
Alt Symbol CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
Species Human
Gene Type protein-coding
Description caspase recruitment domain family, member 8
Other Description CARD inhibitor of NF-kappaB-activating ligands|apoptotic protein NDPP1|caspase recruitment domain-containing protein 8|tumor up-regulated CARD-containing antagonist of CASP9|tumor up-regulated CARD-containing antagonist of caspase nine
Swissprots B7Z496 E9PEM7 Q6PGP8 Q9Y2G2 Q96P82 B5KVR6 G3XAM9 B7Z4A2
Accessions CAC34902 EAW52319 EAW52320 EAW52321 EAW52322 EAW52323 EAW52324 EAW52325 Q9Y2G2 AB023172 BAA76799 AF143869 AF322184 AAG50014 AF331519 AAK01126 AF405558 AAL02427 AF511652 AAM46959 AI040349 AK094933 AK297045 BAH12482 AK297069 BAH12488 AK302327 BAH13675 AK311077 AK311079 AY026322 AAK08982 BC034564 BC041697 BC045539 AAH45539 BC046136 BC056891 AAH56891 BX641091 CAE46043 BX648568 CA448628 CB119078 DC404273 EU118120 ABW96891 EU118121 ABW96892 EU118122 ABW96893 XM_006723091 XP_006723154 XM_006723092 XP_006723155 XM_006723093 XP_006723156 XM_006723094 XP_006723157 XM_006723095 XP_006723158 XM_006723096 XP_006723159 XM_006723097 XP_006723160 XM_006723098 XP_006723161 XM_006723099 XP_006723162 XM_006723101 XP_006723164 XM_006723102 XP_006723165 XM_006723103 XP_006723166 XM_006723104 XP_006723167 XM_006723106 XP_006723169 XM_006723107 XP_006723170 XM_006723109 XP_006723172 XM_006723110 XP_006723173 XM_011526641 XP_011524943 XM_011526642 XP_011524944 XM_011526643 XP_011524945 XM_011526644 XP_011524946 XM_011526645 XP_011524947 XM_011526646 XP_011524948 XM_011526647 XP_011524949 XM_011526648 XP_011524950 XM_011526649 XP_011524951 XM_011526650 XP_011524952 XM_011526651 XP_011524953 XM_011526652 XP_011524954 XM_011526653 XP_011524955 XR_430193 XR_935766 XR_935767 XR_935768 XR_935769 XR_935770 XR_935771 XR_935772 XR_935773 XR_935774 NM_001184900 NP_001171829 NM_001184901 NP_001171830 NM_001184902 NP_001171831 NM_001184903 NP_001171832 NM_001184904 NP_001171833 NM_014959 NP_055774 NR_033678 NR_033679 NR_033680
Function Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15030775}. Nucleus {ECO:0000269|PubMed:15030775}.
Tissue Specificity High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.
Top Pathways NOD-like receptor signaling pathway

CARD 8 (A-18) - sc-68154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CARD 8 (H-111) - sc-292499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CARD 8 (K-18) - sc-68156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CARD 8 (2108C2a) - sc-81213 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CARD 8 (2108C2a): sc-81213 Western Blot analysis of human recombinant CARD 8 fusion protein.

Anti-CARD8 antibody - ab24186 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-CARD8 antibody (ab24186) at 2 µg/ml (CARD8 expression in K562 cell lysate)Lane 2 : Anti-CARD8 antibody (ab24186) at 4 µg/ml (CARD8 expression in K562 cell lysate)Lane 1 : As aboveLane 2 : As above

Anti-CARD8 antibody - ab103488 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CARD8 antibody (ab103488) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-CARD8 antibody - ab115313 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115313 at 5ug/ml staining CARD8 in Human spleen tissue by immunohistochemistry (FFPE). After primary incubation slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-CARD8 antibody - ab153845 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CARD8 antibody (ab153845) at 1/500 dilutionLane 1 : A431 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-CARD8 antibody - ab168472 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CARD8 antibody (ab168472) at 1 µg/mlLane 1 : CARD8 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-CARD8 antibody [2108C2a] - ab50977 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2108C2a
Anti-CARD8 antibody [2108C2a] (ab50977) at 1/200 dilution + HeLa whole cell lysate at 25 µgSecondaryanti-mouse IgG at 1/2500 dilutiondeveloped using the ECL technique

Anti-CARD8 antibody - N-terminal - ab194585 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CARD8 antibody - N-terminal (ab194585) at 1/500 dilutionLane 1 : Extracts from K562 cell lineLane 2 : Extracts from A673 cell lineLane 3 : Extracts from ES2 cell line

Anti-CARD8 / Cardinal / TUCAN Antibody (C-Terminus) - LS-C4317 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C77745 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C306740 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C311039 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C311035 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C335086 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CARD8 antibody.

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C48643 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CARD8 / TUCAN antibody LS-C48643.

Anti-CARD8 / Cardinal / TUCAN Antibody (aa20-69) - LS-C201649 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal spleen. CARD8 antibody dilution 1.0 ug/ml.

Anti-CARD8 / Cardinal / TUCAN Antibody (clone 2108C2a) - LS-C184338 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2108C2a
Immunofluorescent staining using CARD8 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CARD8 antibody.

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C192244 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CARD8 pAb in extracts from K562 and Hela cells.

Anti-CARD8 / Cardinal / TUCAN Antibody (aa125-146) - LS-C148306 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed, paraffin-embedded human colon tissue sections labeled for TUCAN using LS-C148306 at 1:2000. Hematoxylin-Eosin counterstain. A, normal adjacent colonic epithelium. B, matched malignant colonic epithelium shown in a region of invasive cancer. A and B are from the same colon carcinoma patient.

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C155193 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CARD8 / Cardinal / TUCAN Antibody - LS-C148305 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed, paraffin-embedded tumor/normal adjacent tissue cores from a human colontissue microarray stained for TUCAN/CARD8 expression at 1:2000 using LS-C148305. A and B are tumor tissue cores. A1 and B1 are the matched normal adjacent cores from A and B, respectively. Hematoxylin-Eos in counterstain.

Anti-CARD8 / Cardinal / TUCAN Antibody (clone 2108C2a) - LS-C342392 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2108C2a
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CARD8 mAb.
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