TDRD1

Gene Symbol TDRD1
Entrez Gene 56165
Alt Symbol CT41.1
Species Human
Gene Type protein-coding
Description tudor domain containing 1
Other Description cancer/testis antigen 41.1|tudor domain containing protein 1|tudor domain-containing protein 1
Swissprots A6NMN2 Q9BXT4 Q9H7B3 B3KVI4 A6NEN3 B4E2L5 Q6P518 D3DRC2 Q4G0Y8
Accessions EAW49476 EAW49477 EAW49478 EAW49479 EAW49480 Q9BXT4 AF285606 AAK31985 AK024735 BAB14982 AK122916 BAG53796 AK304331 BAG65177 AL833340 BC035010 AAH35010 BC063133 AAH63133 BQ882979 BX648664 CB136029 XM_005269978 XP_005270035 XM_005269979 XP_005270036 XM_011539959 XP_011538261 XM_011539960 XP_011538262 XM_011539961 XP_011538263 XM_011539962 XP_011538264 XM_011539963 XP_011538265 XM_011539964 XP_011538266 XM_011539965 XP_011538267 XM_011539966 XP_011538268 NM_198795 NP_942090
Function Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}.
Tissue Specificity Testis and ovary specific. Also expressed in several cancers. {ECO:0000269|PubMed:12704671}.

TDRD1 (D-17) - sc-165663 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TDRD1 antibody - ab107665 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab107665 stained MCF7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab107665, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TDRD1 antibody - ab168113 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TDRD1 antibody (ab168113) at 1 µg/mlLane 1 : TDRD1 transfected 293T cell lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG

Anti-TDRD1 Antibody (aa837-968) - LS-C182960 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995, APC) - LS-C241680 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995, AP) - LS-C241679 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995, Biotin) - LS-C241682 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995, PE) - LS-C241684 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995, FITC) - LS-C241683 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995, Azide-free, HRP) - LS-C247042 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa973-1002) - LS-C325647 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 Antibody (aa966-995) - LS-C161784 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TDRD1 Antibody western blot of K562 cell line lysates (35 ug/lane). The TDRD1 antibody detected the TDRD1 protein (arrow).

TDRD1 Antibody - AF6296 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of human testis tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human TDRD1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6296) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). Specific bands were detected for TDRD1 at approximately 75 and 120 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

TDRD1 Antibody - NBP1-84349 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TDRD1 Antibody [NBP1-84349] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

TDRD1 Antibody - NBP1-84348 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TDRD1 Antibody - NBP2-11487 from Novus Biologicals

Prices $449.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TDRD1 Antibody - H00056165-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

TDRD1 Antibody [FITC] - NBP2-11488 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

TDRD1 POLYCLONAL ANTIBODY - bs-2186R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TDRD1 antibody produced in mouse - SAB1407732 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TDRD1: <B>Cat. No. SAB1407732</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~130.8 kDa using TDRD1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-TDRD1 antibody produced in rabbit - HPA037730 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TDRD1: <B>Cat. No. HPA037730</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells of tubules.

TDRD1-Antibody-C-term - AP11148b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
TDRD1 Antibody (C-term) (Cat. #AP11148b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TDRD1 antibody detected the TDRD1 protein (arrow).

TDRD1 Antibody - C-terminal region (OAAB07392) - OAAB07392 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Mouse TDRD1 Antibody - MAB6296 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clone 739206
TDRD1 in Mouse Testis. TDRD1 was detected in perfusion fixed frozen sections of mouse testis using Rat Anti-Mouse TDRD1 Monoclonal Antibody (Catalog # MAB6296) at 25 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # NL013 ) and counterstained with DAPI (blue). Specific staining was localized to spermatogonia. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections .

Mouse TDRD1 MAb (Clone 739206), Rat IgG2A - MAB6296-SP from R&D Systems

Host Rat
Clonality Monoclonal
Clone 739206
TDRD1 in Mouse Testis. TDRD1 was detected in perfusion fixed frozen sections of mouse testis using Rat Anti-Mouse TDRD1 Monoclonal Antibody (Catalog # MAB6296) at 25 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # NL013) and counterstained with DAPI (blue). Specific staining was localized to spermatogonia. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
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