| Gene Symbol | TDRD1 |
|---|---|
| Entrez Gene | 56165 |
| Alt Symbol | CT41.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tudor domain containing 1 |
| Other Description | cancer/testis antigen 41.1|tudor domain containing protein 1|tudor domain-containing protein 1 |
| Swissprots | A6NMN2 Q9BXT4 Q9H7B3 B3KVI4 A6NEN3 B4E2L5 Q6P518 D3DRC2 Q4G0Y8 |
| Accessions | EAW49476 EAW49477 EAW49478 EAW49479 EAW49480 Q9BXT4 AF285606 AAK31985 AK024735 BAB14982 AK122916 BAG53796 AK304331 BAG65177 AL833340 BC035010 AAH35010 BC063133 AAH63133 BQ882979 BX648664 CB136029 XM_005269978 XP_005270035 XM_005269979 XP_005270036 XM_011539959 XP_011538261 XM_011539960 XP_011538262 XM_011539961 XP_011538263 XM_011539962 XP_011538264 XM_011539963 XP_011538265 XM_011539964 XP_011538266 XM_011539965 XP_011538267 XM_011539966 XP_011538268 NM_198795 NP_942090 |
| Function | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}. |
| Tissue Specificity | Testis and ovary specific. Also expressed in several cancers. {ECO:0000269|PubMed:12704671}. |
TDRD1 CRISPR/Cas9 KO Plasmid (h) - sc-410043 from Santa Cruz Biotechnology
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TDRD1 HDR Plasmid (h) - sc-410043-HDR from Santa Cruz Biotechnology
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TDRD1 Double Nickase Plasmid (h) - sc-410043-NIC from Santa Cruz Biotechnology
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TDRD1 Double Nickase Plasmid (h2) - sc-410043-NIC-2 from Santa Cruz Biotechnology
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TDRD1 CRISPR Activation Plasmid (h) - sc-410043-ACT from Santa Cruz Biotechnology
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TDRD1 CRISPR Activation Plasmid (h2) - sc-410043-ACT-2 from Santa Cruz Biotechnology
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TDRD1 Lentiviral Activation Particles (h) - sc-410043-LAC from Santa Cruz Biotechnology
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TDRD1 Lentiviral Activation Particles (h2) - sc-410043-LAC-2 from Santa Cruz Biotechnology
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TDRD1 siRNA (h) - sc-90747 from Santa Cruz Biotechnology
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TDRD1 shRNA Plasmid (h) - sc-90747-SH from Santa Cruz Biotechnology
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TDRD1 shRNA (h) Lentiviral Particles - sc-90747-V from Santa Cruz Biotechnology
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TDRD1 RNAi - H00056165-R01 from Novus Biologicals
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MISSION® esiRNA - EHU131211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21185 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21185 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12329 from Sigma-Aldrich
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TDRD1 siRNA (Human) - CRJ1101 from Cohesion Biosciences
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TDRD1 - MBS8205630 from MyBioSource
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shRNA set against Human TDRD1 (NM_198795.1) - SHH425328 from Creative biogene
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Human TDRD1 siRNA - orb271602 from Biorbyt
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TDRD1 shRNA Plasmid (Human) - CHJ1101 from Cohesion Biosciences
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TDRD1 miRNA 3'UTR clone - MiUTR1H-10299 from Creative biogene
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