Gene Symbol | TCHH |
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Entrez Gene | 7062 |
Alt Symbol | THH, THL, TRHY |
Species | Human |
Gene Type | protein-coding |
Description | trichohyalin |
Other Description | - |
Swissprots | Q5VUI3 Q07283 |
Accessions | AAA65582 AAB27489 CCQ43387 Q07283 AK307946 AY827491 AAX12418 BC131826 AAI31827 BC131827 AAI31828 NM_007113 NP_009044 |
Function | Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. |
Tissue Specificity | Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium. |
Trichohyalin CRISPR/Cas9 KO Plasmid (h) - sc-401940 from Santa Cruz Biotechnology
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Trichohyalin HDR Plasmid (h) - sc-401940-HDR from Santa Cruz Biotechnology
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Trichohyalin Double Nickase Plasmid (h) - sc-401940-NIC from Santa Cruz Biotechnology
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Trichohyalin Double Nickase Plasmid (h2) - sc-401940-NIC-2 from Santa Cruz Biotechnology
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Trichohyalin CRISPR Activation Plasmid (h) - sc-401940-ACT from Santa Cruz Biotechnology
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Trichohyalin CRISPR Activation Plasmid (h2) - sc-401940-ACT-2 from Santa Cruz Biotechnology
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Trichohyalin Lentiviral Activation Particles (h) - sc-401940-LAC from Santa Cruz Biotechnology
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Trichohyalin Lentiviral Activation Particles (h2) - sc-401940-LAC-2 from Santa Cruz Biotechnology
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Trichohyalin siRNA (h) - sc-106636 from Santa Cruz Biotechnology
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Trichohyalin shRNA Plasmid (h) - sc-106636-SH from Santa Cruz Biotechnology
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Trichohyalin shRNA (h) Lentiviral Particles - sc-106636-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21152 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21152 from Sigma-Aldrich
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TCHH siRNA (Human) - CRH4833 from Cohesion Biosciences
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TCHH - MBS8207020 from MyBioSource
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shRNA set against Human TCHH (NM_007113.2) - SHH424928 from Creative biogene
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TCHH shRNA Plasmid (Human) - CHH4833 from Cohesion Biosciences
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TCHH miRNA 3'UTR clone - MiUTR3H-02285 from Creative biogene
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