MET
| Gene Symbol | MET |
|---|---|
| Entrez Gene | 4233 |
| Alt Symbol | AUTS9, HGFR, RCCP2, c-Met |
| Species | Human |
| Gene Type | protein-coding |
| Description | MET proto-oncogene, receptor tyrosine kinase |
| Other Description | HGF receptor|HGF/SF receptor|SF receptor|hepatocyte growth factor receptor|met proto-oncogene tyrosine kinase|proto-oncogene c-Met|scatter factor receptor|tyrosine-protein kinase Met |
| Swissprots | O60366 P08581 Q12875 E7EQ94 A1L467 B5A932 Q9UDX7 Q9UPL8 |
| Accessions | AAA59585 AAA59589 AAB54047 AAC60383 AAF66137 EAL24359 EAW83507 EAW83508 EAW83509 EAW83510 EAW83511 P08581 AA278232 AB209898 BAD93135 AF075090 AI630755 AK025784 AK296974 BAG59517 AK298552 BAG60748 AK309532 BC016592 BC027979 AAH27979 BC127890 AAI27891 BC130420 AAI30421 BX648782 DQ656040 EU176015 ABX52004 EU826567 ACF47603 EU826568 ACF47604 EU826569 ACF47605 EU826570 ACF47606 EU826571 ACF47607 EU826572 ACF47608 EU826573 ACF47609 EU826574 ACF47610 EU826575 ACF47611 EU826576 ACF47612 EU826577 ACF47613 EU826578 ACF47614 EU826579 ACF47615 EU826580 ACF47616 EU826581 ACF47617 J02958 AAA59591 M35074 AAA59590 U11813 AAA68513 X54559 CAB56793 XM_006715990 XP_006716053 XM_006715991 XP_006716054 XM_011516223 XP_011514525 NM_000245 NP_000236 NM_001127500 NP_001120972 |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, parti |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. {ECO:0000269|PubMed:1719465, ECO:0000269|PubMed:1917129}. |
| Top Pathways | Bacterial invasion of epithelial cells, MicroRNAs in cancer, Central carbon metabolism in cancer, Rap1 signaling pathway, PI3K-Akt signaling pathway |
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