MET

Gene Symbol	MET
Entrez Gene	4233
Alt Symbol	AUTS9, HGFR, RCCP2, c-Met
Species	Human
Gene Type	protein-coding
Description	MET proto-oncogene, receptor tyrosine kinase
Other Description	HGF receptor|HGF/SF receptor|SF receptor|hepatocyte growth factor receptor|met proto-oncogene tyrosine kinase|proto-oncogene c-Met|scatter factor receptor|tyrosine-protein kinase Met
Swissprots	O60366 P08581 Q12875 E7EQ94 A1L467 B5A932 Q9UDX7 Q9UPL8
Accessions	AAA59585 AAA59589 AAB54047 AAC60383 AAF66137 EAL24359 EAW83507 EAW83508 EAW83509 EAW83510 EAW83511 P08581 AA278232 AB209898 BAD93135 AF075090 AI630755 AK025784 AK296974 BAG59517 AK298552 BAG60748 AK309532 BC016592 BC027979 AAH27979 BC127890 AAI27891 BC130420 AAI30421 BX648782 DQ656040 EU176015 ABX52004 EU826567 ACF47603 EU826568 ACF47604 EU826569 ACF47605 EU826570 ACF47606 EU826571 ACF47607 EU826572 ACF47608 EU826573 ACF47609 EU826574 ACF47610 EU826575 ACF47611 EU826576 ACF47612 EU826577 ACF47613 EU826578 ACF47614 EU826579 ACF47615 EU826580 ACF47616 EU826581 ACF47617 J02958 AAA59591 M35074 AAA59590 U11813 AAA68513 X54559 CAB56793 XM_006715990 XP_006716053 XM_006715991 XP_006716054 XM_011516223 XP_011514525 NM_000245 NP_000236 NM_001127500 NP_001120972
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, parti
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. {ECO:0000269|PubMed:1719465, ECO:0000269|PubMed:1917129}.
Top Pathways	Bacterial invasion of epithelial cells, MicroRNAs in cancer, Central carbon metabolism in cancer, Rap1 signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Met siRNA II - 6622 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Met siRNA I - 6618 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Met CRISPR/Cas9 KO Plasmid (h) - sc-400101 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Met HDR Plasmid (h) - sc-400101-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Met Double Nickase Plasmid (h) - sc-400101-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Met Double Nickase Plasmid (h2) - sc-400101-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Met CRISPR Activation Plasmid (h) - sc-400101-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Met CRISPR Activation Plasmid (h2) - sc-400101-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Met Lentiviral Activation Particles (h) - sc-400101-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Met Lentiviral Activation Particles (h2) - sc-400101-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Met siRNA (h) - sc-29397 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Met shRNA Plasmid (h) - sc-29397-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Met shRNA (h) Lentiviral Particles - sc-29397-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU091731 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1286 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1284 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1285 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1916 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1916 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MET siRNA (Human) - CRH2876 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HGF R/c-MET RNAi - H00004233-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MET(NM_000245.2) - SHH185249 from Creative biogene Category siRNA Species Reactivities Human

Human MET siRNA - orb263378 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MET shRNA Plasmid (Human) - CHH2876 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MET miRNA 3'UTR clone - MiUTR1H-06213 from Creative biogene Species Reactivities Human

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