Gene Symbol | DOK6 |
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Entrez Gene | 220164 |
Alt Symbol | DOK5L, HsT3226 |
Species | Human |
Gene Type | protein-coding |
Description | docking protein 6 |
Other Description | downstream of tyrosine kinase 6 |
Swissprots | Q8WUZ8 A6NNG3 Q6PKX4 Q96LU2 Q96HI2 Q4V9S3 |
Accessions | EAW66514 Q6PKX4 AK057795 BAB71577 AL512695 AY599248 AAT09770 BC008583 AAH08583 BC019045 AAH19045 BC096744 AAH96744 BX280184 DB480182 XM_011525873 XP_011524175 XM_011525874 XP_011524176 XM_011525875 XP_011524177 XM_011525876 XP_011524178 NM_152721 NP_689934 |
Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance. {ECO:0000269|PubMed:15286081}. |
Tissue Specificity | Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. {ECO:0000269|PubMed:15286081}. |
Dok-6 CRISPR/Cas9 KO Plasmid (h) - sc-410651 from Santa Cruz Biotechnology
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Dok-6 HDR Plasmid (h) - sc-410651-HDR from Santa Cruz Biotechnology
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Dok-6 Double Nickase Plasmid (h) - sc-410651-NIC from Santa Cruz Biotechnology
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Dok-6 Double Nickase Plasmid (h2) - sc-410651-NIC-2 from Santa Cruz Biotechnology
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Dok-6 CRISPR Activation Plasmid (h) - sc-410651-ACT from Santa Cruz Biotechnology
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Dok-6 CRISPR Activation Plasmid (h2) - sc-410651-ACT-2 from Santa Cruz Biotechnology
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Dok-6 Lentiviral Activation Particles (h) - sc-410651-LAC from Santa Cruz Biotechnology
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Dok-6 Lentiviral Activation Particles (h2) - sc-410651-LAC-2 from Santa Cruz Biotechnology
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Dok-6 siRNA (h) - sc-60547 from Santa Cruz Biotechnology
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Dok-6 shRNA Plasmid (h) - sc-60547-SH from Santa Cruz Biotechnology
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Dok-6 shRNA (h) Lentiviral Particles - sc-60547-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU103051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7432 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7432 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06330 from Sigma-Aldrich
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DOK6 siRNA (Human) - CRJ6462 from Cohesion Biosciences
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DOK6 - MBS8203455 from MyBioSource
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shRNA set against Human DOK6 (NM_152721.5) - SHH280325 from Creative biogene
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Human DOK6 siRNA - orb276963 from Biorbyt
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DOK6 shRNA Plasmid (Human) - CHJ6462 from Cohesion Biosciences
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