EXOC7
| Gene Symbol | EXOC7 |
|---|---|
| Entrez Gene | 23265 |
| Alt Symbol | 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W |
| Species | Human |
| Gene Type | protein-coding |
| Description | exocyst complex component 7 |
| Other Description | exocyst complex component Exo70 |
| Swissprots | Q8ND93 Q9H8C3 Q9H9X3 Q8WV91 Q9UPT5 B8XXP2 B5MC69 Q9HA32 Q96FF0 |
| Accessions | AAC25180 EAW89367 EAW89368 EAW89369 EAW89370 EAW89371 EAW89372 EAW89373 EAW89374 Q9UPT5 AA215645 AB028990 BAA83019 AI565863 AI653861 AK000718 AK022397 BAB14026 AK022552 BAB14095 AK023832 BAB14694 AK024769 AK098284 AK128278 AK295871 BAG58669 AL162005 AL834324 CAD38992 AY869728 AAW65095 BC011045 AAH11045 BC015165 AAH15165 BC018466 AAH18466 BC029432 BX647763 CAH56185 BX648435 CB989148 DA224278 DC319923 FJ457119 ACK36853 FJ457120 ACK36854 HY020675 XM_006721786 XP_006721849 XM_006721787 XP_006721850 XM_006721788 XP_006721851 XM_006721789 XP_006721852 XM_011524571 XP_011522873 XM_011524572 XP_011522874 NM_001013839 NP_001013861 NM_001145297 NP_001138769 NM_001145298 NP_001138770 NM_001145299 NP_001138771 NM_001282313 NP_001269242 NM_001282314 NP_001269243 NM_015219 NP_056034 |
| Function | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. {ECO:0000250}. |
| Top Pathways | Insulin signaling pathway |
Exo70 CRISPR/Cas9 KO Plasmid (h) - sc-404051 from Santa Cruz Biotechnology
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Exo70 HDR Plasmid (h) - sc-404051-HDR from Santa Cruz Biotechnology
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Exo70 Double Nickase Plasmid (h) - sc-404051-NIC from Santa Cruz Biotechnology
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Exo70 Double Nickase Plasmid (h2) - sc-404051-NIC-2 from Santa Cruz Biotechnology
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Exo70 CRISPR Activation Plasmid (h) - sc-404051-ACT from Santa Cruz Biotechnology
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Exo70 CRISPR Activation Plasmid (h2) - sc-404051-ACT-2 from Santa Cruz Biotechnology
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Exo70 Lentiviral Activation Particles (h) - sc-404051-LAC from Santa Cruz Biotechnology
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Exo70 Lentiviral Activation Particles (h2) - sc-404051-LAC-2 from Santa Cruz Biotechnology
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Exo70 siRNA (h) - sc-94143 from Santa Cruz Biotechnology
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Exo70 shRNA Plasmid (h) - sc-94143-SH from Santa Cruz Biotechnology
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Exo70 shRNA (h) Lentiviral Particles - sc-94143-V from Santa Cruz Biotechnology
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EXOC7 RNAi - H00023265-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8042 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8042 from Sigma-Aldrich
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EXOC7 siRNA (Human) - CRH8136 from Cohesion Biosciences
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EXOC7 RNAi - H00023265-R02 from Novus Biologicals
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EXOC7 - MBS8223134 from MyBioSource
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shRNA set against Human EXOC7 (NM_015219.3) - SHH288041 from Creative biogene
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EXOC7 shRNA Plasmid (Human) - CHH8136 from Cohesion Biosciences
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EXOC7 miRNA 3'UTR clone - MiUTR4H-TG03207 from Creative biogene
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