KNTC1

Gene Symbol KNTC1
Entrez Gene 9735
Alt Symbol ROD
Species Human
Gene Type protein-coding
Description kinetochore associated 1
Other Description Rough Deal homolog, centromere/kinetochore protein|kinetochore-associated protein 1
Swissprots B3KSG2 A7E2C4 P50748
Accessions EAW98333 EAW98334 P50748 AA157787 AI916095 AK093470 BAG52724 AK293403 BAG56910 AK303337 BAG64400 BC055410 BC150278 AAI50279 D79988 BAA11483 XM_006719706 XP_006719769 XM_011539027 XP_011537329 XM_011539028 XP_011537330 XM_011539029 XP_011537331 XM_011539030 XP_011537332 XR_944844 XR_944845 XR_944846 NM_014708 NP_055523
Function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131}.
Subcellular Location Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.
Tissue Specificity High expression in testis.

ROD CRISPR/Cas9 KO Plasmid (h) - sc-405696 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD HDR Plasmid (h) - sc-405696-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD Double Nickase Plasmid (h) - sc-405696-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD Double Nickase Plasmid (h2) - sc-405696-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD CRISPR Activation Plasmid (h) - sc-405696-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD CRISPR Activation Plasmid (h2) - sc-405696-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD Lentiviral Activation Particles (h) - sc-405696-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD Lentiviral Activation Particles (h2) - sc-405696-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ROD siRNA (h) - sc-62958 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ROD shRNA Plasmid (h) - sc-62958-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ROD shRNA (h) Lentiviral Particles - sc-62958-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU044431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11336 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11336 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00376 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00376

KNTC1 siRNA (Human) - CRH6503 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KNTC1 RNAi - H00009735-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KNTC1(NM_014708.4) - SHL204794 from Creative biogene

Category siRNA
Species Reactivities Human

Human KNTC1 siRNA - orb267005 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KNTC1 shRNA Plasmid (Human) - CHH6503 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KNTC1 miRNA 3'UTR clone - MiUTR1H-05422 from Creative biogene

Species Reactivities Human
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