Gene Symbol | ZFAT |
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Entrez Gene | 57623 |
Alt Symbol | AITD3, ZFAT1, ZNF406 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger and AT hook domain containing |
Other Description | zinc finger gene in autoimmune thyroid disease|zinc finger protein 406|zinc finger protein ZFAT|zinc-finger gene in AITD susceptibility region |
Swissprots | Q75PJ9 Q3MIM5 Q9P243 Q86X64 E9PER3 Q6PJ01 B7ZL15 Q75PJ6 Q75PJ7 |
Accessions | EAW92179 Q9P243 AB040918 BAA96009 AB167738 BAD12567 AB167739 BAD12568 AB167740 BAD12569 AB167741 BAD12570 AK094089 AK300133 BAH13220 AK300324 BAH13257 AK300471 BAH13290 AK301413 BAH13477 AK311494 AL832066 BC012989 AAH12989 BC025423 AAH25423 BC039059 BC046180 AAH46180 BC070097 BC098405 AAH98405 BC101766 AAI01767 BC101768 AAI01769 BC143519 AAI43520 BI964061 BM685256 DC333809 XM_011517203 XP_011515505 XM_011517204 XP_011515506 XM_011517205 XP_011515507 XM_011517206 XP_011515508 XR_928343 NM_001029939 NP_001025110 NM_001167583 NP_001161055 NM_001174157 NP_001167628 NM_001174158 NP_001167629 NM_001289394 NP_001276323 NM_020863 NP_065914 NR_110323 |
Function | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
Tissue Specificity | Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes. {ECO:0000269|PubMed:15294872}. |
ZFAT CRISPR/Cas9 KO Plasmid (h) - sc-418355 from Santa Cruz Biotechnology
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ZFAT HDR Plasmid (h) - sc-418355-HDR from Santa Cruz Biotechnology
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ZFAT Double Nickase Plasmid (h) - sc-418355-NIC from Santa Cruz Biotechnology
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ZFAT Double Nickase Plasmid (h2) - sc-418355-NIC-2 from Santa Cruz Biotechnology
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ZFAT CRISPR Activation Plasmid (h) - sc-418355-ACT from Santa Cruz Biotechnology
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ZFAT CRISPR Activation Plasmid (h2) - sc-418355-ACT-2 from Santa Cruz Biotechnology
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ZFAT Lentiviral Activation Particles (h) - sc-418355-LAC from Santa Cruz Biotechnology
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ZFAT Lentiviral Activation Particles (h2) - sc-418355-LAC-2 from Santa Cruz Biotechnology
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ZFAT siRNA (h) - sc-77821 from Santa Cruz Biotechnology
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ZFAT shRNA Plasmid (h) - sc-77821-SH from Santa Cruz Biotechnology
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ZFAT shRNA (h) Lentiviral Particles - sc-77821-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23166 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23166 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06028 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12970 from Sigma-Aldrich
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ZFAT siRNA (Human) - CRJ1590 from Cohesion Biosciences
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ZNF406 RNAi - H00057623-R01 from Novus Biologicals
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ZNF406 RNAi - H00057623-R02 from Novus Biologicals
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ZFAT - MBS8238783 from MyBioSource
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shRNA set against Human Zfat (NM_020863.3) - SHH450220 from Creative biogene
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Human ZFAT siRNA - orb272091 from Biorbyt
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ZFAT shRNA Plasmid (Human) - CHJ1590 from Cohesion Biosciences
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ZFAT miRNA 3'UTR clone - MiUTR3H-11558 from Creative biogene
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ZFAT miRNA 3'UTR clone - MiUTR3H-11559 from Creative biogene
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