| Gene Symbol | ATF6B |
|---|---|
| Entrez Gene | 1388 |
| Alt Symbol | CREB-RP, CREBL1, G13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | activating transcription factor 6 beta |
| Other Description | Creb-related protein|cAMP response element-binding protein-related protein|cAMP responsive element binding protein-like 1|cAMP-dependent transcription factor ATF-6 beta|cAMP-responsive element-binding protein-like 1|cyclic AMP-dependent transcription factor ATF-6 beta|protein G13 |
| Swissprots | Q13269 Q99635 Q9NPL0 Q14343 B0UYX6 Q9H3V9 Q9H3W1 Q99941 Q5SSW7 Q99637 Q14345 |
| Accessions | AAB47487 AAG14898 AAG14900 CAA66663 CAB89295 EAX03581 EAX03582 EAX03583 EAX03584 EAX03585 Q99941 AK000928 BC008394 AAH08394 BC077075 AAH77075 BT007042 AAP35691 U31903 AAA97438 U52696 U52701 X98054 CAA66664 NM_001136153 NP_001129625 NM_004381 NP_004372 |
| Function | Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Estrogen signaling pathway, Thyroid hormone synthesis, cGMP-PKG signaling pathway, Dopaminergic synapse, Adrenergic signaling in cardiomyocytes |