Gene Symbol | ATF6B |
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Entrez Gene | 1388 |
Alt Symbol | CREB-RP, CREBL1, G13 |
Species | Human |
Gene Type | protein-coding |
Description | activating transcription factor 6 beta |
Other Description | Creb-related protein|cAMP response element-binding protein-related protein|cAMP responsive element binding protein-like 1|cAMP-dependent transcription factor ATF-6 beta|cAMP-responsive element-binding protein-like 1|cyclic AMP-dependent transcription factor ATF-6 beta|protein G13 |
Swissprots | Q13269 Q99635 Q9NPL0 Q14343 B0UYX6 Q9H3V9 Q9H3W1 Q99941 Q5SSW7 Q99637 Q14345 |
Accessions | AAB47487 AAG14898 AAG14900 CAA66663 CAB89295 EAX03581 EAX03582 EAX03583 EAX03584 EAX03585 Q99941 AK000928 BC008394 AAH08394 BC077075 AAH77075 BT007042 AAP35691 U31903 AAA97438 U52696 U52701 X98054 CAA66664 NM_001136153 NP_001129625 NM_004381 NP_004372 |
Function | Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Estrogen signaling pathway, Thyroid hormone synthesis, cGMP-PKG signaling pathway, Dopaminergic synapse, Adrenergic signaling in cardiomyocytes |
ATF-6β siRNA (h) - sc-105103 from Santa Cruz Biotechnology
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ATF-6β shRNA Plasmid (h) - sc-105103-SH from Santa Cruz Biotechnology
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ATF-6β shRNA (h) Lentiviral Particles - sc-105103-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU111821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3638 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3638 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03935 from Sigma-Aldrich
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ATF6B siRNA (Human) - CRH0974 from Cohesion Biosciences
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ATF6 beta RNAi - H00001388-R01 from Novus Biologicals
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ATF6B - MBS8208593 from MyBioSource
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ATF6B shRNA Plasmid (Human) - CHH0974 from Cohesion Biosciences
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ATF6B miRNA 3'UTR clone - MiUTR3H-03787 from Creative biogene
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ATF6B miRNA 3'UTR clone - MiUTR3H-03788 from Creative biogene
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