SENP6

Gene Symbol SENP6
Entrez Gene 26054
Alt Symbol SSP1, SUSP1
Species Human
Gene Type protein-coding
Description SUMO1/sentrin specific peptidase 6
Other Description 2810017C20Rik|SUMO-1-specific protease 1|SUMO1/sentrin specific protease 6|sentrin-specific protease 6|sentrin/SUMO-specific protease SENP6
Swissprots Q5VUL4 Q9UJV5 Q5VUL3 O94891 Q9GZR1 A6NNY9 Q8TBY4
Accessions CCQ43516 CCQ43517 EAW48733 EAW48734 EAW48735 EAW48736 Q9GZR1 AA768785 AB018340 BAA34517 AF196304 AAF04852 AF306508 AAG30253 AF307849 AAG29831 AI732829 AJ710192 AK001406 BAG50906 AK021417 BAG51032 AK021949 BAG51063 AK096455 BAC04794 AK126921 BAG54398 BC028583 AAH28583 CR990444 XM_006715457 XP_006715520 XM_011535745 XP_011534047 XM_011535746 XP_011534048 XM_011535747 XP_011534049 XR_241847 NM_001100409 NP_001093879 NM_001304792 NP_001291721 NM_015571 NP_056386
Function Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875}.
Tissue Specificity Highly expressed in reproductive organs, such as testis, ovary and prostate.

SENP6 (C-14) - sc-47379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SENP6 (C-14): sc-47379. Western blot analysis of SENP6 expression in HeLa (A) and LNCaP (B) whole cell lysates.

SENP6 (79-M) - sc-100585 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SENP6 (79-M): sc-100585. Western blot analysis of SENP6 expression in IMR-32 whole cell lysate.

Anti-SENP6 antibody - ab57239 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SENP6 antibody (ab57239) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human stomach.

Anti-SENP6 antibody - ab58421 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human lung carcinoma tissue using ab58421 at 1/50 dilution, in the absence or presence of the immunizing peptide.

Anti-SENP6 antibody - Carboxyterminal end - ab59899 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SENP6 antibody - Carboxyterminal end (ab59899) at 1/100 dilution + HL60 cell lysateSecondaryHRP-anti-rabbitdeveloped using the ECL technique

Anti-SENP6 antibody - N-terminal - ab176452 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SENP6 antibody - N-terminal (ab176452) at 1/1000 dilution + Mouse brain total cell extracts

Anti-SENP6 Antibody (aa1096-1112) - LS-C10091 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa712-725) - LS-C91285 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa2-14) - LS-C55541 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SENP6 Antibody (aa712-725) - LS-C191286 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody - LS-C191287 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa1083-1112, AP) - LS-C240559 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa1083-1112, APC) - LS-C240560 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa1083-1112, Biotin) - LS-C240562 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa1083-1112, FITC) - LS-C240563 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa1042-1091) - LS-C118616 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma, using SENP6 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-SENP6 Antibody (aa1083-1112, PE) - LS-C240564 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa788-837) - LS-C151261 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SENP6 antibody Western Blot of Mouse Lung.

Anti-SENP6 Antibody (aa900-929, AP) - LS-C240565 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa900-929, Biotin) - LS-C240567 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa900-929, APC) - LS-C240566 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa900-929, FITC) - LS-C240568 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (aa900-929, PE) - LS-C240573 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP6 Antibody (C-Terminus) - LS-C81580 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-SENP6 Antibody (N-Terminus, AP) - LS-C245754 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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