SENP6

Gene Symbol	SENP6
Entrez Gene	26054
Alt Symbol	SSP1, SUSP1
Species	Human
Gene Type	protein-coding
Description	SUMO1/sentrin specific peptidase 6
Other Description	2810017C20Rik|SUMO-1-specific protease 1|SUMO1/sentrin specific protease 6|sentrin-specific protease 6|sentrin/SUMO-specific protease SENP6
Swissprots	Q5VUL4 Q9UJV5 Q5VUL3 O94891 Q9GZR1 A6NNY9 Q8TBY4
Accessions	CCQ43516 CCQ43517 EAW48733 EAW48734 EAW48735 EAW48736 Q9GZR1 AA768785 AB018340 BAA34517 AF196304 AAF04852 AF306508 AAG30253 AF307849 AAG29831 AI732829 AJ710192 AK001406 BAG50906 AK021417 BAG51032 AK021949 BAG51063 AK096455 BAC04794 AK126921 BAG54398 BC028583 AAH28583 CR990444 XM_006715457 XP_006715520 XM_011535745 XP_011534047 XM_011535746 XP_011534048 XM_011535747 XP_011534049 XR_241847 NM_001100409 NP_001093879 NM_001304792 NP_001291721 NM_015571 NP_056386
Function	Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875}.
Tissue Specificity	Highly expressed in reproductive organs, such as testis, ovary and prostate.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SENP6 protein fragment - ab125841 from Abcam Category Protein Source E. coli Species Human

Human SENP6 peptide - ab23114 from Abcam Category Peptide Species Human

SENP6 Antibody Blocking Peptide - LS-E1642 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP6 Antibody Blocking Peptide - LS-E25598 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP6 Antibody Blocking Peptide - LS-E18262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP6 Antibody Blocking Peptide - LS-E18263 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP6 Antibody Blocking Peptide - LS-E26616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SENP6 Protein - H00026054-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SENP6 Peptide - P0304 from Novus Biologicals Category Peptide Species Human

SENP6-Antibody-C-term-Blocking-Peptide - BP1239a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SENP6/SUSP1 blocking peptide - GTX88791-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

SUSP1/SSP1 blocking peptide - GTX25901-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

SENP6 Blocking Peptide - 33R-6250 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SENP6 Blocking Peptide - abx161220 from Abbexa Category Peptide Species Human, Mouse, Rat

SENP6 Peptide - AC21-0428-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SENP6 Peptide - AC21-1452-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SENP6 - H00026054-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SENP6 - H00026054-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SSP1 Peptide - 46-434P from ProSci Category Peptide

SUSP1 Peptide - 46-711P from ProSci Category Peptide Species Human

Recombinant Human SENP6, His-tagged - SENP6-182H from Creative Biomart Category Protein Source E. coli Species Human

SENP6 Blocking Peptide - CBP3719 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SENP6 (K1077) Peptide - BS1473P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Sentrin-specific protease 6(SENP6) ,partial - CSB-YP867110HU CSB-EP867110HU CSB-BP867110HU CSB-MP867110HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SENP6, Peptide - MBS633772 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Human, Rat

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