| Gene Symbol |
OTUB2
|
| Entrez Gene |
78990
|
| Alt Symbol |
C14orf137, OTB2, OTU2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
OTU deubiquitinase, ubiquitin aldehyde binding 2
|
| Other Description |
OTU domain, ubiquitin aldehyde binding 2|OTU domain-containing ubiquitin aldehyde-binding protein 2|deubiquitinating enzyme OTUB2|otubain-2|ubiquitin thioesterase OTUB2|ubiquitin-specific protease otubain 2|ubiquitin-specific-processing protease OTUB2
|
| Swissprots |
Q9H6T1 Q96DC9 Q6IA10
|
| Accessions |
EAW81548 EAW81549 Q96DC9 AF318378 AAL55885 AI018242 AK025569 BAB15172 AY177201 AAO27703 BC000208 AAH00208 BC009615 AAH09615 BC068058 AAH68058 BG423958 CR457345 CAG33626 HQ447541 ADQ32027 XM_005268055 XP_005268112 XM_006725171 XP_006725234 XM_011537147 XP_011535449 XM_011537148 XP_011535450 XM_011537149 XP_011535451 XM_011546664 XP_011544966 XM_011546665 XP_011544967 XM_011546666 XP_011544968 NM_023112 NP_075601
|
| Function |
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'- linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:18954305, ECO:0000269|PubMed:23827681}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in brain. {ECO:0000269|PubMed:12704427}.
|
![Western Blot: OTUB2 Overexpression Lysate (Adult Normal) [NBL1-14012] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OTUB2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3316_OTUB2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14012-img0002.jpg)