IL12RB1

Gene Symbol	IL12RB1
Entrez Gene	3594
Alt Symbol	CD212, IL-12R-BETA1, IL12RB, IMD30
Species	Human
Gene Type	protein-coding
Description	interleukin 12 receptor, beta 1
Other Description	IL-12 receptor beta component|IL-12 receptor subunit beta-1|IL-12R subunit beta-1|cluster of differentiation 212|interleukin-12 receptor beta-1 chain|interleukin-12 receptor subunit beta-1
Swissprots	B2RPF1 P42701 Q8N6Q7 B7ZKK3 A8K308
Accessions	AAV28734 CAC10446 EAW84653 EAW84654 EAW84655 EAW84656 P42701 AI637915 AK225919 AK290423 BAF83112 BC029121 AAH29121 BC137404 AAI37405 BC137406 AAI37407 BX647221 DA008204 EU832463 ACE87635 EU832511 ACE87683 EU832545 ACE86947 EU832592 ACE86994 JF432889 ADZ16106 U03187 AAA21340 XM_006722741 XP_006722804 XM_011527966 XP_011526268 XM_011527967 XP_011526269 XM_011527968 XP_011526270 XM_011527969 XP_011526271 XM_011527970 XP_011526272 XM_011527971 XP_011526273 XM_011527972 XP_011526274 XM_011527973 XP_011526275 XM_011527974 XP_011526276 XM_011527975 XP_011526277 XM_011527976 XP_011526278 XM_011527977 XP_011526279 NM_001290023 NP_001276952 NM_001290024 NP_001276953 NM_005535 NP_005526 NM_153701 NP_714912
Function	Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. {ECO:0000269|PubMed:12023369}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL12RB1 full length protein - ab152476 from Abcam Category Protein Source Wheat germ Species Human

Human IL12RB1 protein fragment - ab201886 from Abcam Category Protein Source Insect cells Species Human

Human IL12RB1 protein fragment - ab202232 from Abcam Category Protein Source E. coli Species Human

IL12RB1 / CD212 Antibody Blocking Peptide - LS-E27385 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL-12 R beta 1 Recombinant Protein - H00003594-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL-12 R beta 1 Recombinant Protein - H00003594-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

IL12 Receptor beta1 blocking peptide - GTX88103-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human IL-12 R beta 1 Fc Chimera, CF - 839-B1-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

IL12RB1 protein - 80R-4220 from Fitzgerald Category Protein Prices $295.00 Sizes 50 µg Source Insect cells

IL12RB1 protein (His tag) - 80R-4079 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

Human IL12Rb1 Protein - abx067435 from Abbexa Category Protein Source E.coli Species Human

Human IL12Rb1 Protein - abx067434 from Abbexa Category Protein Source E.coli Species Human

IL12RB1 Peptide - AC21-2209-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD212 / IL12RB1 (1-545, His-tag) - AR51765PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

CD212 / IL12RB1 (1-545, His-tag) - AR51765PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

CD212 / IL12RB1 (24-545, His-tag) - AR51902PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Species Human

CD212 / IL12RB1 (24-545, His-tag) - AR51902PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Species Human

CD212 / IL12RB1 - H00003594-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD212 / IL12RB1 - H00003594-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD212 / IL12RB1 - H00003594-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Interleukin 12 Receptor Beta 1 (IL12Rb1), Human - 20-7875 from ARP American Research Products Category Protein Prices $559.00 Sizes 50 µg Source E.coli Species Human

Interleukin 12 Receptor Beta 1 (IL12Rb1), Human - 20-7876 from ARP American Research Products Category Protein Prices $559.00 Sizes 50 µg Source E.coli Species Human

IL12RB1 Peptide - 42-602P from ProSci Category Peptide Species Human

IL12RB1 fusion protein - ag6920 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IL12RB1 fusion protein - ag3983 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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