| Gene Symbol |
F3
|
| Entrez Gene |
2152
|
| Alt Symbol |
CD142, TF, TFA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coagulation factor III (thromboplastin, tissue factor)
|
| Other Description |
tissue factor
|
| Swissprots |
Q6FHG2 Q86WH4 P13726 D3DT47
|
| Accessions |
AAA61152 AAN01236 CAA01438 EAW73043 EAW73044 EAW73045 P13726 AF487337 AAO61150 AF497569 AAO61151 AF497570 AAO61152 AF497571 AAO61153 AK310918 AK312638 BAG35522 AY940729 AY940730 AY940731 BC011029 AAH11029 BM769013 BM981095 BT019808 AAV38611 CR541792 CAG46591 DB203987 DB499288 DQ892755 ABM83681 J02931 AAA61150 M16553 AAA61151 M27436 AAA36734 X07680 CAA30527 NM_001178096 NP_001171567 NM_001993 NP_001984
|
| Function |
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293}.
|
| Subcellular Location |
Isoform 1: Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Lung, placenta and pancreas. {ECO:0000269|PubMed:12652293}.
|
| Top Pathways |
Complement and coagulation cascades
|
