| Gene Symbol |
RHBDF1
|
| Entrez Gene |
64285
|
| Alt Symbol |
C16orf8, Dist1, EGFR-RS, gene-89, gene-90, hDist1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
rhomboid 5 homolog 1 (Drosophila)
|
| Other Description |
epidermal growth factor receptor, related sequence|epidermal growth factor receptor-related protein|iRhom1|inactive rhomboid protein 1|p100hRho|rhomboid family 1|rhomboid family member 1
|
| Swissprots |
Q1W6H2 Q4TT59 Q96S34 Q96CC6 Q04842 Q9H6E1
|
| Accessions |
AAK61212 ABD95905 CAG27587 CAI95607 CAI95608 CAI95609 CAM26658 CAX15112 EAW85873 EAW85874 EAW85875 EAW85876 Q96CC6 AK026010 BAB15318 AK056708 BAG51794 AK225408 AK291177 BAF83866 AK304797 BAG65547 AK304812 BAG65562 AK309097 BC014425 AAH14425 BM830007 M99624 AAA02490 XM_005255494 XP_005255551 XM_005255498 XP_005255555 XM_006720921 XP_006720984 XM_011522598 XP_011520900 XM_011522599 XP_011520901 XM_011522600 XP_011520902 NM_022450 NP_071895
|
| Function |
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the endoplasmic reticulum membrane.
|
| Tissue Specificity |
Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:8318735}.
|
